Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 7/20 | 0.35 |
| ▸ | RAB9A | P51151 | 8/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.33 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 5/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3797366 | 0.96 | BRD4 (0.46) | BRD4HTTRAB9AGRM5PABPC1 | |
| SCHEMBL14751267 | 0.82 | BRD4 (0.41) | BRD4HTTRAB9AGRM5PABPC1 | |
| SCHEMBL23082898 | 0.81 | RAB9A (0.41) | BRD4HTTRAB9APABPC1APOBEC3A | |
| SCHEMBL8324035 | 0.81 | BRD4 (0.40) | BRD4HTTRAB9AGRM5PABPC1 | |
| SCHEMBL24959143 | 0.81 | BRD4 (0.40) | BRD4HTTRAB9AGRM5PABPC1 | |
| SCHEMBL3796955 | 0.81 | BRD4 (0.40) | BRD4HTTRAB9AGRM5PABPC1 | |
| SCHEMBL14751327 | 0.78 | BRD4 (0.44) | BRD4HTTRAB9AGRM5PABPC1 | |
| SCHEMBL3796853 | 0.77 | BRD4 (0.43) | BRD4HTTRAB9AGRM5PABPC1 | |
| SCHEMBL20631132 | 0.74 | LMNA (0.32) | BRD4LMNAGAANPSR1 | |
| SCHEMBL3799033 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010117425-A1 | CERTAIN SUBSTITUTED PYRIMIDINES, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE | BIOGEN IDEC MA INC. (US) | 2010-10-14 | — | — | WO | disclosed |