Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 2/20 | 0.34 |
| ▸ | F2 | P00734 | 2/20 | 0.34 |
| ▸ | GLS | O94925 | 1/20 | 0.34 |
| ▸ | PTGER2 | P43116 | 6/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.32 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.32 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.32 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.32 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.32 |
| ▸ | CLK1 | P49759 | 1/20 | 0.31 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3654305 | 0.93 | GPBAR1 (0.35) | SOS1NAMPTF2GLSPTGER2 | |
| SCHEMBL4132659 | 0.87 | NAMPT (0.39) | NAMPTPTGER2 | |
| SCHEMBL3648432 | 0.87 | GPBAR1 (0.39) | NAMPTF2PTGER2HTR2CSLC6A4 | |
| SCHEMBL3649650 | 0.83 | NAMPT (0.36) | SOS1NAMPTF2GLSPTGER2 | |
| SCHEMBL3799201 | 0.82 | PTGER2 (0.35) | NAMPTPTGER2ABCC9ABCC8KCNJ11 | |
| SCHEMBL3650554 | 0.81 | HTR2C (0.37) | SOS1NAMPTF2GLSHTR2C | |
| SCHEMBL3654644 | 0.79 | HTR2C (0.38) | SOS1F2GLSHTR2CSLC6A4 | |
| SCHEMBL3654491 | 0.79 | NAMPT (0.35) | SOS1NAMPTF2GLSPTGER2 | |
| SCHEMBL3654948 | 0.79 | F2 (0.35) | SOS1F2GLSHTR2CSLC6A4 | |
| Carbamic Acid SCHEMBL3651234 | 0.79 | HTR2C (0.37) | SOS1F2GLSHTR2CSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2190822-A2 | 5-MEMBERED HETEROCYCLIC COMPOUNDS AS PROTON PUMP INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009041705-A9 | 5-MEMBERED HETEROCYCLIC COMPOUNDS AS PROTON PUMP INHIBITORS | TAKEDA PHARMACEUTICAL (JP) | 2009-08-13 | — | — | WO | disclosed |
| WO-2009041705-A2 | 5-MEMBERED HETEROCYCLIC COMPOUNDS AS PROTON PUMP INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-04-02 | — | — | WO | disclosed |