Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER2 | P43116 | 6/20 | 0.35 |
| ▸ | NAMPT | P43490 | 6/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.32 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.32 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.32 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3654310 | 0.93 | GPBAR1 (0.34) | PTGER2NAMPT | |
| SCHEMBL3648440 | 0.87 | GPBAR1 (0.38) | PTGER2NAMPTMAPTLMNATP53 | |
| SCHEMBL4132659 | 0.86 | NAMPT (0.39) | PTGER2NAMPTKDM4EMAPTKCNA5 | |
| SCHEMBL3649653 | 0.82 | PTGER2 (0.39) | PTGER2NAMPTKMT2ALMNATP53 | |
| SCHEMBL3799197 | 0.82 | SOS1 (0.35) | PTGER2NAMPTABCC9ABCC8KCNJ11 | |
| SCHEMBL3650557 | 0.81 | GPBAR1 (0.35) | NAMPTKDM4EKMT2A | |
| SCHEMBL3654647 | 0.80 | CNR2 (0.35) | KDM4EMAPTKMT2ALMNA | |
| Carbamic Acid SCHEMBL3651238 | 0.79 | CA12 (0.33) | KDM4EMAPTKMT2ALMNA | |
| SCHEMBL3652839 | 0.79 | CTSK (0.32) | NAMPT | |
| SCHEMBL3654497 | 0.79 | GPBAR1 (0.36) | PTGER2NAMPTKMT2ALMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2190822-A2 | 5-MEMBERED HETEROCYCLIC COMPOUNDS AS PROTON PUMP INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009041705-A9 | 5-MEMBERED HETEROCYCLIC COMPOUNDS AS PROTON PUMP INHIBITORS | TAKEDA PHARMACEUTICAL (JP) | 2009-08-13 | — | — | WO | disclosed |
| WO-2009041705-A2 | 5-MEMBERED HETEROCYCLIC COMPOUNDS AS PROTON PUMP INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-04-02 | — | — | WO | disclosed |