Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASPH | Q12797 | 4/20 | 0.76 |
| ▸ | KDM8 | Q8N371 | 4/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.76 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.54 |
| ▸ | KDM5A | P29375 | 1/20 | 0.49 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.49 |
| ▸ | VNN1 | O95497 | 3/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.46 |
| ▸ | CLK1 | P49759 | 1/20 | 0.46 |
| ▸ | CLK2 | P49760 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4901416 | 0.79 | CLK4 (0.50) | ASPHKDM8KDM4EVNN1CLK4 | |
| SCHEMBL4855920 | 0.74 | KDM4C (0.76) | ASPHKDM8KDM4ERIOX2KDM5A | |
| SCHEMBL1715769 | 0.74 | NPC1 (0.66) | ASPHKDM8KDM4ERIOX2KDM5B | |
| SCHEMBL24157190 | 0.74 | KDM4E (0.65) | ASPHKDM8KDM4ERIOX2VNN1 | |
| SCHEMBL7823324 | 0.74 | MCHR1 (0.61) | ASPHKDM8KDM4ERIOX2VNN1 | |
| SCHEMBL30253210 | 0.74 | KDM4E (0.65) | ASPHKDM8KDM4ERIOX2VNN1 | |
| SCHEMBL3730790 | 0.74 | KDM4E (0.76) | ASPHKDM8KDM4ERIOX2VNN1 | |
| SCHEMBL6103515 | 0.73 | KDM4E (0.53) | ASPHKDM8KDM4ERIOX2KDM5B | |
| SCHEMBL31139804 | 0.73 | KDM4E (0.53) | ASPHKDM8KDM4ERIOX2KDM5B | |
| SCHEMBL24987203 | 0.73 | KDM4E (0.50) | ASPHKDM8KDM4ERIOX2VNN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7825132-B2 | Inhibition of FGFR3 and treatment of multiple myeloma | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2010-11-02 | — | — | US | disclosed |
| US-20050261307-A1 | Inhibition of FGFR3 and treatment of multiple myeloma | CHIRON CORPORATION | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261307-A1 | Inhibition of FGFR3 and treatment of multiple myeloma | FGFR3, FGFR1, FGFR2 | ASPH 1666/4885KDM8 1560/4885KDM4E 3240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.