Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.50 |
| ▸ | CLK1 | P49759 | 3/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.50 |
| ▸ | CLK2 | P49760 | 2/20 | 0.50 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ASPH | Q12797 | 1/20 | 0.50 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | VNN1 | O95497 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16332117 | 0.83 | KDM4E (0.50) | CLK4CLK1DYRK1ACLK2DYRK1B | |
| SCHEMBL30148165 | 0.81 | CLK4 (0.50) | CLK4CLK1DYRK1ACLK2DYRK1B | |
| SCHEMBL2450873 | 0.81 | CLK4 (0.50) | CLK4CLK1DYRK1ACLK2DYRK1B | |
| SCHEMBL3799558 | 0.79 | ASPH (0.76) | CLK4CLK1DYRK1ACLK2DYRK1B | |
| SCHEMBL13351975 | 0.74 | NPC1 (0.52) | CLK4CLK1DYRK1ACLK2DYRK1B | |
| SCHEMBL25750998 | 0.73 | CLK4 (0.48) | CLK4CLK1DYRK1ACLK2DYRK1B | |
| SCHEMBL12362922 | 0.72 | CLK4 (0.67) | CLK4CLK1DYRK1ACLK2DYRK1B | |
| SCHEMBL5233252 | 0.72 | HTT (0.58) | KDM4EALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL29634669 | 0.72 | HTT (0.58) | KDM4EALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL21382408 | 0.71 | NPC1 (0.62) | CLK4DYRK1ANPC1BCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080221132-A1 | Multi-Functional Small Molecules as Anti-Proliferative Agents | CURIS, INC. | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221132-A1 | Multi-Functional Small Molecules as Anti-Proliferative Agents | HDAC1, HDAC6, HDAC5 | CLK4 1166/4885CLK1 771/4885DYRK1A 1512/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.