Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 16/20 | 0.58 |
| ▸ | JAK1 | P23458 | 3/20 | 0.44 |
| ▸ | JAK3 | P52333 | 3/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL913775 | 0.90 | SYK (0.61) | SYKJAK1JAK3JAK2TYK2 | |
| SCHEMBL3786482 | 0.88 | SYK (0.61) | SYK | |
| SCHEMBL3791847 | 0.85 | SYK (0.63) | SYK | |
| SCHEMBL913562 | 0.79 | SYK (0.54) | SYKJAK1JAK3JAK2 | |
| SCHEMBL912917 | 0.79 | SYK (0.59) | SYKJAK1JAK3JAK2TYK2 | |
| SCHEMBL12904904 | 0.78 | SYK (0.53) | SYKJAK1JAK3JAK2 | |
| SCHEMBL912987 | 0.78 | SYK (0.65) | SYK | |
| SCHEMBL737072 | 0.77 | SYK (0.71) | SYK | |
| SCHEMBL912992 | 0.77 | SYK (0.53) | SYKJAK1JAK3 | |
| SCHEMBL3790334 | 0.76 | JAK3 (0.60) | SYKJAK1JAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129802-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | WO | disclosed |