Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 16/20 | 0.60 |
| ▸ | JAK2 | O60674 | 8/20 | 0.52 |
| ▸ | JAK1 | P23458 | 6/20 | 0.52 |
| ▸ | STAT6 | P42226 | 3/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL912912 | 0.87 | JAK3 (0.67) | JAK3JAK2JAK1STAT6 | |
| SCHEMBL3793017 | 0.82 | SYK (0.49) | STAT6SYK | |
| SCHEMBL22261209 | 0.81 | JAK3 (0.79) | JAK3JAK2JAK1 | |
| SCHEMBL3792397 | 0.80 | MAPK8 (0.49) | STAT6SYK | |
| SCHEMBL913067 | 0.77 | STAT6 (0.59) | JAK3JAK2JAK1STAT6SYK | |
| SCHEMBL3800518 | 0.76 | SYK (0.58) | JAK3JAK2JAK1SYK | |
| SCHEMBL3786482 | 0.76 | SYK (0.61) | SYK | |
| SCHEMBL22261282 | 0.76 | JAK3 (0.79) | JAK3JAK2JAK1 | |
| SCHEMBL22261046 | 0.75 | JAK3 (0.81) | JAK3JAK2JAK1 | |
| SCHEMBL3793275 | 0.75 | SYK (0.59) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129802-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | WO | disclosed |