Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 5/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 5/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 5/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.50 |
| ▸ | SCN1A | P35498 | 1/20 | 0.50 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.50 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 7/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL567675 | 0.85 | ADRA2A (0.50) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL566815 | 0.84 | ADRA2A (0.56) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL566566 | 0.81 | ADRA2A (0.57) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL567729 | 0.80 | ADRA2A (0.51) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL566662 | 0.79 | ADRA2A (0.50) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL3805300 | 0.79 | DRD2 (0.48) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL567146 | 0.78 | ADRA2A (0.58) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL566779 | 0.78 | ADRA2A (0.48) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL567283 | 0.76 | ADRA2A (0.58) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL30495456 | 0.76 | ADRA2A (0.58) | ADRA2AADRA2BADRA2CADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2176252-A1 | 2, 3-DIHYDROBENZO[1, 4]DIOXIN-2-YLMETHYL DERIVATIVES AS ALPHA2C ANTAGONISTS FOR USE IN THE TREATMENT OF PERIPHERIC AND CENTRAL NERVOUS SYSTEME DISEASES | ORION CORPORATION (FI) | 2010-04-21 | — | — | EP | disclosed |
| WO-2009013390-A1 | 2, 3-DIHYDROBENZO[1, 4] DIOXIN-2-YLMETHYL DERIVATIVES AS ALPHA2C ANTAGONISTS FOR USE IN THE TREATMENT OF PERIPHERIC AND CENTRAL NERVOUS SYSTEME DISEASES | ORION CORPORATION (FI) | 2009-01-29 | — | — | WO | disclosed |