Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.73 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | ME2 | P23368 | 2/20 | 0.62 |
| ▸ | ME1 | P48163 | 2/20 | 0.62 |
| ▸ | ME3 | Q16798 | 2/20 | 0.62 |
| ▸ | GFER | P55789 | 1/20 | 0.61 |
| ▸ | NAAA | Q02083 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7131839 | 0.91 | NPC1 (0.86) | NPC1TDP1FKBP1AKMT2AMAPT | |
| SCHEMBL14747850 | 0.87 | NPC1 (0.73) | NPC1TDP1FKBP1AKMT2AMAPT | |
| SCHEMBL9819732 | 0.85 | TSHR (0.71) | NPC1TDP1FKBP1AKMT2AMAPT | |
| SCHEMBL3796874 | 0.85 | NPC1 (0.75) | NPC1TDP1FKBP1AKMT2AMAPT | |
| SCHEMBL25432319 | 0.84 | NPC1 (0.93) | NPC1TDP1FKBP1AKMT2AMAPT | |
| SCHEMBL3700679 | 0.84 | NPC1 (1.00) | NPC1TDP1FKBP1AKMT2AMAPT | |
| SCHEMBL8984794 | 0.84 | NPC1 (0.69) | NPC1TDP1FKBP1AKMT2AMAPT | |
| SCHEMBL9410811 | 0.83 | NPC1 (0.73) | NPC1TDP1FKBP1AKMT2AMAPT | |
| SCHEMBL10163014 | 0.83 | NPC1 (0.73) | NPC1TDP1FKBP1AKMT2AMAPT | |
| SCHEMBL17087869 | 0.83 | NPC1 (0.96) | NPC1TDP1FKBP1AKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140088095-A1 | METHOD FOR TREATING PAIN, ANXIETY OR DEPRESSION USING CARBAMOYLOXY ALKANOYL PIPERAZINE COMPOUND | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2014-03-27 | — | — | US | disclosed |
| US-20100160331-A1 | NOVEL CARBAMOYLOXY ARYLALKAN ARYLPIPERAZINE COMPOUND, PHARMACEUTICAL COMPOSITIONS COMPRISING THE COMPOUND AND METHOD FOR TREATING PAIN, ANXIETY AND DEPRESSION BY ADMINISTERING THE COMPOUND | SK HOLDINGS CO. LTD. (KR) | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160331-A1 | NOVEL CARBAMOYLOXY ARYLALKAN ARYLPIPERAZINE COMPOUND, PHARMACEUTICAL COMPOSITIONS COMPRISING THE COMPOUND AND METHOD FOR TREATING PAIN, ANXIETY AND DEPRESSION BY ADMINISTERING THE COMPOUND | HTR5A, OPRD1, OPRL1 | NPC1 1042/4885TDP1 3341/4885FKBP1A 1218/4885 |
| US-20140088095-A1 | METHOD FOR TREATING PAIN, ANXIETY OR DEPRESSION USING CARBAMOYLOXY ALKANOYL PIPERAZINE COMPOUND | HTR5A, OPRL1, HDAC3 | NPC1 1383/4885TDP1 3476/4885FKBP1A 1140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.