Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 3/20 | 0.33 |
| ▸ | KHK | P50053 | 3/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 3/20 | 0.32 |
| ▸ | HTR2B | P41595 | 2/20 | 0.32 |
| ▸ | DRD4 | P21917 | 2/20 | 0.31 |
| ▸ | DRD3 | P35462 | 2/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HRH1 | P35367 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3731483 | 0.74 | HTR2C (0.34) | PDE10AADRB2SLC6A4HTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL3740335 | 0.73 | HTR2C (0.33) | PDE10AALDH1A1ADRB2SLC6A4HTR2C | |
| SCHEMBL10650868 | 0.64 | DHFR (0.61) | — | |
| SCHEMBL5097183 | 0.62 | KHK (0.54) | KHK | |
| SCHEMBL18484592 | 0.60 | HTR2C (0.45) | ALDH1A1HTR2CKDM4E | |
| SCHEMBL30883037 | 0.60 | HSP90AA1 (0.48) | PDE10AALDH1A1ADRB2LMNAHSP90AA1 | |
| SCHEMBL7113990 | 0.59 | GABRA1 (0.36) | ALDH1A1LMNA | |
| SCHEMBL21003289 | 0.58 | PARP1 (0.31) | ALDH1A1KDM4E | |
| SCHEMBL15318169 | 0.58 | HSP90AA1 (0.43) | PDE10AALDH1A1ADRB2LMNAHSP90AA1 | |
| SCHEMBL19222487 | 0.58 | HRH2 (0.34) | HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2242757-A1 | PYRAZOLOPYRIDINES AS KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2010-10-27 | — | — | EP | disclosed |
| WO-2009089359-A1 | PYRAZOLOPYRIDINES AS KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2009-07-16 | — | — | WO | disclosed |