Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 4/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 3/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL380112 | 0.82 | MAPK13 (0.76) | MAPK13MAPK14KDM4EPDE2APDE10A | |
| SCHEMBL379882 | 0.75 | MAPK13 (0.78) | MAPK13MAPK14PDE2A | |
| SCHEMBL379821 | 0.74 | MAPK13 (0.74) | MAPK13MAPK14KDM4EPDE2APDE10A | |
| SCHEMBL379963 | 0.74 | MAPK13 (0.71) | MAPK13MAPK14 | |
| SCHEMBL380637 | 0.73 | MAPK13 (0.77) | MAPK13MAPK14 | |
| SCHEMBL379824 | 0.73 | MAPK13 (0.75) | MAPK13MAPK14HSD11B1 | |
| SCHEMBL380253 | 0.73 | MAPK13 (0.74) | MAPK13MAPK14 | |
| SCHEMBL380034 | 0.71 | MAPK13 (1.00) | MAPK13MAPK14 | |
| SCHEMBL380661 | 0.71 | MAPK13 (0.73) | MAPK13MAPK14 | |
| SCHEMBL13385743 | 0.70 | HSD11B1 (0.53) | MAPK13ALDH1A1KDM4EPDE2AHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086973-B1 | IMIDAZO- AND TRIAZOLO-PYRIDINE COMPOUNDS AND METHODS OF USE THEROF | AMGEN INC (US) | 2012-01-25 | — | — | EP | disclosed |