SCHEMBL3801432

SCHEMBL3801432

O=C(c1ccccc1)C1CNCCN1C(=O)O

nearest known ligand 0.46

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 1/20 0.46
USP2 O75604 1/20 0.42
ALDH1A1 P00352 1/20 0.42
TSHR P16473 1/20 0.42
HSD17B10 Q99714 1/20 0.42
CA1 P00915 2/20 0.40
CA2 P00918 2/20 0.40
CA4 P22748 2/20 0.40
CA9 Q16790 2/20 0.40
CHRNB2 P17787 2/20 0.40
CHRNB4 P30926 2/20 0.40
CHRNA3 P32297 2/20 0.40
CHRNA7 P36544 2/20 0.40
CHRNA4 P43681 2/20 0.40
HTR2C P28335 1/20 0.38
OPRD1 P41143 1/20 0.38
KMT2A Q03164 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5313826 0.91 HPGD (0.41) SIGMAR1CA1CA2CA4CA9
SCHEMBL11590269 0.89 SIGMAR1 (0.53) SIGMAR1CA1CA2CA4CA9
SCHEMBL8498078 0.88 SIGMAR1 (0.44) SIGMAR1USP2ALDH1A1TSHRHSD17B10
SCHEMBL3666620 0.85 SMN1; SMN2 (0.42) ALDH1A1CHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL3671778 0.85 NPSR1 (0.43) SIGMAR1HTR2C
SCHEMBL28214604 0.84 SIGMAR1 (0.41) SIGMAR1USP2ALDH1A1TSHRHSD17B10
SCHEMBL22467693 0.81 SIGMAR1 (0.46) SIGMAR1USP2ALDH1A1TSHRHSD17B10
SCHEMBL28978028 0.81 MAPK1 (0.43) SIGMAR1KMT2A
SCHEMBL28978066 0.80 HTR2C (0.50) TSHRHTR2CKMT2A
SCHEMBL8595770 0.80 SLC6A2 (0.49) SIGMAR1USP2ALDH1A1TSHRHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023081452-A1 SMALL-MOLECULE DEGRADERS OF CDK8 AND CDK19 UNIVERSITY OF SOUTH CAROLINA (US) 2023-05-11 WO disclosed
EP-2150532-A1 PIPERAZINE COMPOUNDS FOR THE INHIBITION OF HAEMATOPOIETIC PROSTAGLANDIN D SYNTHASE Evotec AG (DE) 2010-02-10 EP disclosed
WO-2008122787-A1 PIPERAZINE COMPOUNDS FOR THE INHIBITION OF HAEMATOPOIETIC PROSTAGLANDIN D SYNTHASE EVOTEC AG (DE) 2008-10-16 WO disclosed