Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 2/20 | 0.38 |
| ▸ | SKP1 | P63208 | 2/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.38 |
| ▸ | MTOR | P42345 | 3/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.37 |
| ▸ | FEN1 | P39748 | 2/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3087904 | 0.85 | PIK3CG (0.42) | CKS1BSKP1SKP2PIK3CAPIK3CB | |
| SCHEMBL3085473 | 0.74 | BACE1 (0.42) | CKS1BSKP1SKP2NR1H2TBK1 | |
| SCHEMBL13706388 | 0.74 | PIK3CA (0.43) | PIK3CAPIK3CBMTORPIK3CGPIK3CD | |
| SCHEMBL3635690 | 0.74 | PIK3CA (0.43) | PIK3CAPIK3CBMTORPIK3CGGPR119 | |
| SCHEMBL3078390 | 0.73 | CKS1B (0.51) | CKS1BSKP1SKP2PIK3CAPIK3CB | |
| SCHEMBL3085931 | 0.72 | PIK3CG (0.68) | CKS1BSKP1SKP2PIK3CAPIK3CB | |
| SCHEMBL3092295 | 0.69 | PIK3CG (0.45) | CKS1BSKP1SKP2PIK3CAPIK3CB | |
| SCHEMBL1583147 | 0.69 | GPR119 (0.58) | CKS1BSKP1SKP2ALDH1A1GPR119 | |
| SCHEMBL3091985 | 0.67 | PIK3CG (0.47) | PIK3CAPIK3CBMTORPIK3CGPIK3CD | |
| SCHEMBL189681 | 0.65 | MAPT (0.61) | TGFBR1KDM4EALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150255-A1 | QUINOXALINE DERIVATIVES AS P13 KINASE INHIBITORS | Smithkline Beecham Corporation (US) | 2010-02-10 | — | — | EP | disclosed |
| WO-2008141065-A1 | QUINOXALINE DERIVATIVES AS P13 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-11-20 | — | — | WO | disclosed |