Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 2/20 | 0.53 |
| ▸ | SRD5A2 | P31213 | 4/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 9/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SHBG | P04278 | 1/20 | 0.38 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.38 |
| ▸ | GUSB | P08236 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | G6PD | P11413 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10273329 | 0.93 | CYP19A1 (0.46) | SRD5A1CYP19A1 | |
| SCHEMBL7529519 | 0.83 | CYP19A1 (0.58) | SRD5A1CYP19A1MEN1LMNASHBG | |
| SCHEMBL3797856 | 0.83 | CYP19A1 (0.58) | SRD5A1CYP19A1MEN1LMNASHBG | |
| SCHEMBL3803500 | 0.81 | SRD5A1 (0.50) | SRD5A1SRD5A2CYP17A1CYP19A1MEN1 | |
| SCHEMBL3803940 | 0.81 | CYP17A1 (0.57) | SRD5A1SRD5A2CYP17A1CYP19A1MEN1 | |
| SCHEMBL3803939 | 0.81 | CYP17A1 (0.57) | SRD5A1SRD5A2CYP17A1CYP19A1MEN1 | |
| SCHEMBL7523372 | 0.81 | CYP17A1 (0.57) | SRD5A1SRD5A2CYP17A1CYP19A1MEN1 | |
| SCHEMBL7523365 | 0.81 | CYP17A1 (0.57) | SRD5A1SRD5A2CYP17A1CYP19A1MEN1 | |
| SCHEMBL7523360 | 0.81 | CYP17A1 (0.57) | SRD5A1SRD5A2CYP17A1CYP19A1MEN1 | |
| SCHEMBL5183886 | 0.81 | SRD5A1 (0.53) | SRD5A1SRD5A2CYP17A1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705273-B1 | 17-HALOGENO-4-AZAANDROSTENE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | RICHTER GEDEON VEGYESZET (HU) | 2002-03-27 | — | — | EP | claimed |
| US-5583228-A | 17-halogeno-4-azaandrostene derivatives and process for the preparation thereof | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 1996-12-10 | — | — | US | claimed |
| EP-0705273-A1 | 17-HALOGENO-4-AZAANDROSTENE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1996-04-10 | — | — | EP | claimed |
| WO-1995000532-A1 | 17-HALOGENO-4-AZAANDROSTENE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 1995-01-05 | — | — | WO | claimed |
| US-20100105700-A1 | DECAHYDRO-1H-INDENOQUINOLINONE AND DECAHYDRO-3H-CYCLOPENTAPHENANTHRIDINONE CYP17 INHIBITORS | LEAD THERAPEUTICS, INC. (US) | 2010-04-29 | — | — | US | disclosed |
| EP-0705273-B1 | 17-HALOGENO-4-AZAANDROSTENE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | RICHTER GEDEON VEGYESZET (HU) | 2002-03-27 | — | — | EP | disclosed |
| EP-0705272-B1 | NOVEL PROCESS FOR PREPARING 17 BETA-SUBSTITUTED 4-AZAANDROSTANE DERIVATIVES | RICHTER GEDEON VEGYESZET (HU) | 2002-03-27 | — | — | EP | disclosed |
| US-5583228-A | 17-halogeno-4-azaandrostene derivatives and process for the preparation thereof | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 1996-12-10 | — | — | US | disclosed |
| US-5583138-A | REDUCTASE INHIBITOR; SKIN DISORDERS | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 1996-12-10 | — | — | US | disclosed |
| EP-0705273-A1 | 17-HALOGENO-4-AZAANDROSTENE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1996-04-10 | — | — | EP | disclosed |
| EP-0705272-A1 | NOVEL PROCESS FOR PREPARING 17 BETA-SUBSTITUTED 4-AZAANDROSTANE DERIVATIVES | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1996-04-10 | — | — | EP | disclosed |
| EP-0662977-A1 | NOVEL 17$g(b)-SUBSTITUTED 4-AZAANDROSTANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1995-07-19 | — | — | EP | disclosed |
| WO-1995000532-A1 | 17-HALOGENO-4-AZAANDROSTENE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 1995-01-05 | — | — | WO | disclosed |
| WO-1995000531-A1 | NOVEL PROCESS FOR PREPARING 17β-SUBSTITUTED 4-AZAANDROSTANE DERIVATIVES | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 1995-01-05 | — | — | WO | disclosed |
| WO-1994007909-A1 | NOVEL 17β-SUBSTITUTED 4-AZAANDROSTANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 1994-04-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105700-A1 | DECAHYDRO-1H-INDENOQUINOLINONE AND DECAHYDRO-3H-CYCLOPENTAPHENANTHRIDINONE CYP17 INHIBITORS | CYP17A1, HSD17B1, CYP21A2 | SRD5A1 24/4885SRD5A2 27/4885CYP17A1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.