Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 19/20 | 0.60 |
| ▸ | TRPV4 | Q9HBA0 | 6/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3791508 | 0.89 | TRPA1 (0.69) | TRPA1TRPV4MAPT | |
| SCHEMBL3794310 | 0.88 | TRPA1 (0.61) | TRPA1TRPV4MAPTSMN1; SMN2 | |
| SCHEMBL3799501 | 0.88 | TRPA1 (0.60) | TRPA1TRPV4 | |
| SCHEMBL3794988 | 0.86 | TRPA1 (0.61) | TRPA1TRPV4 | |
| SCHEMBL3810205 | 0.84 | TRPA1 (0.59) | TRPA1TRPV4MAPTSMN1; SMN2 | |
| SCHEMBL474692 | 0.84 | TRPA1 (0.65) | TRPA1TRPV4MAPTSMN1; SMN2 | |
| SCHEMBL3796445 | 0.84 | TRPA1 (0.81) | TRPA1TRPV4 | |
| SCHEMBL612052 | 0.84 | TRPA1 (0.79) | TRPA1TRPV4MAPTSMN1; SMN2 | |
| SCHEMBL12618156 | 0.84 | TRPA1 (0.84) | TRPA1TRPV4 | |
| SCHEMBL3798786 | 0.83 | TRPA1 (0.72) | TRPA1TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010125469-A1 | PYRIMIDINEDIONE-FUSED HETEROCYCLIC COMPOUNDS AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2010-11-04 | — | — | WO | claimed |
| WO-2010125469-A1 | PYRIMIDINEDIONE-FUSED HETEROCYCLIC COMPOUNDS AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2010-11-04 | — | — | WO | disclosed |