Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.60 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | ACHE | P22303 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 12/20 | 0.53 |
| ▸ | TMEM97 | Q5BJF2 | 10/20 | 0.53 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.53 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15128281 | 0.88 | LMNA (0.63) | LMNASLC22A2SLC22A1ALDH1A1TSHR | |
| SCHEMBL1559831 | 0.88 | HPGD (0.73) | LMNASLC22A2SLC22A1ALDH1A1TSHR | |
| SCHEMBL3030899 | 0.87 | SIGMAR1 (0.70) | ALDH1A1HPGDSIGMAR1TMEM97ACKR3 | |
| SCHEMBL3758442 | 0.83 | LMNA (0.55) | LMNASLC22A2SLC22A1ALDH1A1TSHR | |
| SCHEMBL380130 | 0.82 | TMEM97 (0.72) | LMNAALDH1A1MAPK1SIGMAR1TMEM97 | |
| SCHEMBL2159841 | 0.82 | TSHR (0.83) | LMNASLC22A2SLC22A1ALDH1A1TSHR | |
| SCHEMBL11230329 | 0.82 | KDM4E (0.63) | LMNASLC22A2SLC22A1ALDH1A1TSHR | |
| SCHEMBL12515200 | 0.82 | KDM4E (0.63) | LMNASLC22A2SLC22A1ALDH1A1TSHR | |
| SCHEMBL1409860 | 0.81 | LMNA (0.71) | LMNASLC22A2SLC22A1ALDH1A1TSHR | |
| SCHEMBL3000922 | 0.80 | POLB (0.58) | LMNASLC22A2SLC22A1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476253-B2 | Amide derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-07-02 | — | — | US | disclosed |
| US-20120071467-A1 | AMIDE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-03-22 | — | — | US | disclosed |
| EP-2409977-A1 | AMIDE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2012-01-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071467-A1 | AMIDE DERIVATIVE | CHRM3, CHRM2, TACR2 | LMNA 3813/4885SLC22A2 1280/4885SLC22A1 1891/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.