Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.50 |
| ▸ | CA1 | P00915 | 3/20 | 0.48 |
| ▸ | CA2 | P00918 | 3/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA3 | P07451 | 1/20 | 0.48 |
| ▸ | TYR | P14679 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | CA6 | P23280 | 1/20 | 0.48 |
| ▸ | CA5A | P35218 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.48 |
| ▸ | RXRA | P19793 | 1/20 | 0.47 |
| ▸ | RXRB | P28702 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Paraben SCHEMBL7876194 | 0.92 | CA2 (0.64) | ALDH1A1TSHRTP53SMN1; SMN2SRD5A2 | |
| SCHEMBL502508 | 0.86 | KDM4E (0.55) | ALDH1A1TSHRTP53HPGDRARB | |
| Terephthalic Acid SCHEMBL27306913 | 0.82 | TSHR (0.75) | ALDH1A1TSHRTP53SMN1; SMN2SRD5A2 | |
| Terephthalic Acid SCHEMBL11035242 | 0.79 | TSHR (0.71) | ALDH1A1TSHRTP53SMN1; SMN2SRD5A2 | |
| Terephthalic Acid SCHEMBL1482407 | 0.79 | TSHR (0.71) | ALDH1A1TSHRTP53SMN1; SMN2SRD5A2 | |
| Terephthalic Acid SCHEMBL30899317 | 0.79 | TSHR (0.71) | ALDH1A1TSHRTP53SMN1; SMN2SRD5A2 | |
| SCHEMBL4141280 | 0.77 | ALDH1A1 (0.54) | ALDH1A1TSHRTP53SMN1; SMN2SRD5A2 | |
| Terephthalic Acid SCHEMBL11804308 | 0.77 | TSHR (0.67) | ALDH1A1TSHRTP53SMN1; SMN2SRD5A2 | |
| Terephthalic Acid SCHEMBL21599098 | 0.77 | TSHR (0.67) | ALDH1A1TSHRTP53SMN1; SMN2SRD5A2 | |
| Terephthalic Acid SCHEMBL27916115 | 0.77 | TSHR (0.67) | ALDH1A1TSHRTP53SMN1; SMN2SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1398353-B1 | THERMOPLASTIC RESIN COMPOSITION | KANEKA CORP (JP) | 2010-10-13 | — | — | EP | disclosed |
| US-7282535-B2 | Thermoplastic resin composition | KANEKA CORPORATION (JP) | 2007-10-16 | — | — | US | disclosed |
| US-20040147674-A1 | Thermoplastic resin composition | KANEKA CORPORATION (JP) | 2004-07-29 | — | — | US | disclosed |
| EP-1398353-A1 | THERMOPLASTIC RESIN COMPOSITION | Kaneka Corporation (JP) | 2004-03-17 | — | — | EP | disclosed |
| US-4786685-A | POLYESTER OR POLYCARBONATE BLENDED WITH A HYDROLYZED ETHYLENE-VINYL ACETATE COPOLYMER | NIPPON GOHSEI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1988-11-22 | — | — | US | disclosed |