Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 8/20 | 0.42 |
| ▸ | BACE1 | P56817 | 8/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | INSR | P06213 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALPG | P10696 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3801266 | 0.78 | HSD17B10 (0.45) | ITKCNR2INSRKDM4EALDH1A1 | |
| SCHEMBL3798908 | 0.78 | POLB (0.51) | ITKBACE1CNR2INSR | |
| SCHEMBL3800016 | 0.76 | TLR8 (0.55) | ITKBACE1CNR2 | |
| SCHEMBL19437510 | 0.74 | KMT2A (0.52) | BACE1KDM4EALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL6230957 | 0.73 | KDM4E (0.46) | BACE1CNR2KDM4EALDH1A1LMNA | |
| SCHEMBL3791176 | 0.72 | ITK (0.47) | ITKBACE1CNR2INSR | |
| SCHEMBL2362150 | 0.71 | KDM4E (0.53) | ITKBACE1CNR2KDM4EALDH1A1 | |
| SCHEMBL3797142 | 0.70 | POLB (0.51) | ITKBACE1CNR2ALDH1A1HTT | |
| SCHEMBL2361851 | 0.69 | BACE1 (0.39) | BACE1 | |
| SCHEMBL2362076 | 0.69 | RIPK1 (0.42) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010126922-A1 | BENZIMIDAZOLECARBOXAMIDES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-11-04 | — | — | WO | disclosed |
| WO-2010126922-A1 | BENZIMIDAZOLECARBOXAMIDES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-11-04 | — | — | WO | disclosed |