Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8377343 | 0.98 | DHFR (0.65) | DHFR | |
| Water SCHEMBL28837029 | 0.98 | DHFR (0.65) | DHFR | |
| SCHEMBL9159357 | 0.87 | DHFR (0.76) | DHFR | |
| SCHEMBL8902491 | 0.86 | DHFR (0.68) | DHFR | |
| SCHEMBL1317138 | 0.84 | DHFR (0.54) | DHFR | |
| Sulfanilamide SCHEMBL28020128 | 0.83 | — | — | |
| SCHEMBL3962268 | 0.83 | DHFR (0.60) | DHFR | |
| SCHEMBL6415423 | 0.82 | DHFR (0.49) | DHFR | |
| SCHEMBL3937299 | 0.82 | DHFR (0.68) | DHFR | |
| SCHEMBL11286352 | 0.82 | DHFR (0.68) | DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 263 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2362775-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2011-09-07 | — | — | EP | claimed |
| EP-1230224-B1 | SUBSTITUTED 5-BENZYL-2,4-DIAMINOPYRIMIDINES | BASILEA PHARMACEUTICA AG (CH) | 2004-12-29 | — | — | EP | claimed |
| EP-0793656-B1 | NOVEL BENZYL PYRIMIDINES | BASILEA PHARMACEUTICA AG (CH) | 2003-03-26 | — | — | EP | claimed |
| EP-1230224-A1 | SUBSTITUTED 5-BENZYL-2,4-DIAMINOPYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-08-14 | — | — | EP | claimed |
| WO-2001032633-A1 | SUBSTITUTED 5-BENZYL-2,4-DIAMINOPYRIMIDINES | BASILEA PHARMACEUTICA AG (CH) | 2001-05-10 | — | — | WO | claimed |
| EP-0901473-A1 | NOVEL PIPERAZINYLALKYLTHIOPYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND A PROCESS FOR THE PREPARATION OF THE NOVEL COMPOUNDS | EGIS GYOGYSZERGYAR RT. (HU) | 1999-03-17 | — | — | EP | claimed |
| EP-0793656-A1 | NOVEL BENZYL PYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-09-10 | — | — | EP | claimed |
| WO-1997016429-A1 | NOVEL PIPERAZINYLALKYLTHIOPYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND A PROCESS FOR THE PREPARATION OF THE NOVEL COMPOUNDS | EGIS Gyógyszergyár Rt. (HU) | 1997-05-09 | — | — | WO | claimed |
| WO-1996016046-A2 | NOVEL BENZYL PYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 1996-05-30 | — | — | WO | claimed |
| EP-0231888-B1 | SUBSTITUTED 2,4-DIAMINO-5-BENZYL PYRIMIDINES, THEIR PREPARATION AND THEIR USE AS MEDICINES HAVING AN ANTIMICROBIAN ACTIVITY | Fatol Arzneimittel GmbH (DE) | 1992-12-30 | — | — | EP | claimed |
| EP-0048298-A1 | Use of embonates of 2,4-diamino-benzyl pyrimidines | LUDWIG HEUMANN & CO GMBH (DE) | 1982-03-31 | — | — | EP | claimed |
| EP-0003212-B1 | 2.4-DIAMINO-5-BENZYLPYRIMIDINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR PREPARATION | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-03-17 | — | — | EP | claimed |
| US-4315932-A | AND SULFANILAMIDES | BURROUGHS WELLCOME CO. (US) | 1982-02-16 | — | — | US | claimed |
| EP-0037501-A1 | Pharmaceutical preparations and manufacature | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1981-10-14 | — | — | EP | claimed |
| EP-0000334-B1 | 2,4-DIAMINO-5-BENZYL-PYRIMIDINES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM | BASF Aktiengesellschaft (DE) | 1981-08-12 | — | — | EP | claimed |
| US-4216319-A | Synthesis of 2,4-diamino-5-benzylpyrimidines using benzyl cyanoacetal intermediates | BURROUGHS WELLCOME CO. (US) | 1980-08-05 | — | — | US | claimed |
| EP-0006987-A1 | 2,4-Diamino-5-benzylpyrimidines, especially for the treatment of microbial infections, pharmaceutical compositions containing these compounds and processes for preparing these compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1980-01-23 | — | — | EP | claimed |
| EP-0003212-A1 | 2.4-Diamino-5-benzylpyrimidines, pharmaceutical compositions containing them and their preparation | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1979-08-08 | — | — | EP | claimed |
| US-4116958-A | ORGANIC SYNTHETIC METHODS BENZYLPYRIMIDINE DERIVATIVES | BURROUGHS WELLCOME CO. (US) | 1978-09-26 | — | — | US | claimed |
| US-4094976-A | ANTICOCCIDIAL CYCLICAMINO ETHANOLS AND ESTERS THEREOF | MERCK & CO., INC. (US) | 1978-06-13 | — | — | US | claimed |