Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 8/20 | 0.77 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.65 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3808057 | 1.00 | NQO2 (0.77) | NQO2PTGS1PTGS2ALDH1A1MEN1 | |
| SCHEMBL5181745 | 0.84 | NQO2 (0.54) | NQO2PTGS1ALDH1A1MEN1KMT2A | |
| SCHEMBL1650706 | 0.81 | NQO2 (0.51) | NQO2PTGS1ALDH1A1MEN1KMT2A | |
| SCHEMBL1650710 | 0.81 | NQO2 (0.51) | NQO2PTGS1ALDH1A1MEN1KMT2A | |
| SCHEMBL5453588 | 0.80 | NQO2 (0.69) | NQO2PTGS1PTGS2ALDH1A1MEN1 | |
| SCHEMBL5453595 | 0.80 | NQO2 (0.69) | NQO2PTGS1PTGS2ALDH1A1MEN1 | |
| SCHEMBL5453593 | 0.80 | NQO2 (0.69) | NQO2PTGS1PTGS2ALDH1A1MEN1 | |
| SCHEMBL3811776 | 0.79 | PTGS1 (0.75) | NQO2PTGS1PTGS2 | |
| SCHEMBL3811778 | 0.79 | PTGS1 (0.75) | NQO2PTGS1PTGS2 | |
| SCHEMBL1651929 | 0.79 | NQO2 (0.50) | NQO2PTGS1ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8487009-B2 | 1,2-diphenylethene derivatives for treatment of immune diseases | GLAXO GROUP LIMITED (GB) | 2013-07-16 | — | — | US | claimed |
| US-8487009-B2 | 1,2-diphenylethene derivatives for treatment of immune diseases | GLAXO GROUP LIMITED (GB) | 2013-07-16 | — | — | US | disclosed |
| EP-1368306-B1 | NOVEL 1,2-DIPHENYLETHENE DERIVATIVES FOR TREATMENT OF IMMUNE DISEASES | WELICHEM BIOTECH INC (CA) | 2013-01-16 | — | — | EP | disclosed |
| US-20090149548-A1 | NOVEL 1,2-DIPHENYLETHENE DERIVATIVES FOR TREATMENT OF IMMUNE DISEASES | WELICHEM BIOTECH, INC. (CA) | 2009-06-11 | — | — | US | disclosed |
| US-20040102517-A1 | Modulators of T- cells, neutrophils, macrophages and their associated cytokines | GLAXO GROUP LIMITED (GB) | 2004-05-27 | — | — | US | disclosed |
| EP-1368306-A1 | NOVEL 1,2-DIPHENYLETHENE DERIVATIVES FOR TREATMENT OF IMMUNE DISEASES | Welichem Biotech Inc. (CA) | 2003-12-10 | — | — | EP | disclosed |
| WO-2002057219-A1 | NOVEL 1,2-DIPHENYLETHENE DERIVATIVES FOR TREATMENT OF IMMUNE DISEASES | WELICHEM BIOTECH INC. (CA) | 2002-07-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090149548-A1 | NOVEL 1,2-DIPHENYLETHENE DERIVATIVES FOR TREATMENT OF IMMUNE DISEASES | IL2, IFNG, NFATC1 | NQO2 2224/4885PTGS1 90/4885PTGS2 122/4885 |
| US-20040102517-A1 | Modulators of T- cells, neutrophils, macrophages and their associated cytokines | IL2, NFATC1, IFNG | NQO2 2218/4885PTGS1 188/4885PTGS2 263/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.