Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 11/20 | 0.61 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.47 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.47 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.47 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3635174 | 0.87 | NAMPT (0.59) | NAMPTDGAT1EPHX2TLR9TLR8 | |
| SCHEMBL3634211 | 0.84 | SLC18A3 (0.49) | NAMPTDGAT1 | |
| SCHEMBL17130441 | 0.83 | NAMPT (0.58) | NAMPTDGAT1EPHX2TLR9TLR8 | |
| SCHEMBL3810068 | 0.81 | SLC18A3 (0.54) | NAMPTDGAT1 | |
| SCHEMBL3816677 | 0.80 | SLC18A3 (0.46) | NAMPTDGAT1 | |
| SCHEMBL4672899 | 0.79 | NAMPT (0.61) | NAMPTDGAT1EPHX2TLR9TLR8 | |
| SCHEMBL3809829 | 0.79 | SLC18A3 (0.51) | NAMPTDGAT1 | |
| SCHEMBL16994778 | 0.78 | NAMPT (0.60) | NAMPTDGAT1TLR9TLR8TLR7 | |
| SCHEMBL520567 | 0.78 | NAMPT (0.55) | NAMPTTLR9TLR8TLR7 | |
| SCHEMBL3700011 | 0.77 | NAMPT (1.00) | NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090170864-A1 | Diacylglycerol Acyltransferase Inhibitors | MADRIGAL PHARMACEUTICALS, INC. | 2009-07-02 | — | — | US | disclosed |
| US-20090105273-A1 | Diacylglycerol Acyltransferase Inhibitors | MADRIGAL PHARMACEUTICALS, INC. | 2009-04-23 | — | — | US | disclosed |
| US-20090099201-A1 | Diacylglycerol Acyltransferase Inhibitors | VIA PHARMACEUTICALS, INC. | 2009-04-16 | — | — | US | disclosed |
| US-20090093497-A1 | Diacylglycerol Acyltransferase Inhibitors | MADRIGAL PHARMACEUTICALS, INC. | 2009-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090093497-A1 | Diacylglycerol Acyltransferase Inhibitors | DGAT2, DGAT1, LCAT | NAMPT 291/4885DGAT1 2/4885EPHX2 735/4885 |
| US-20090170864-A1 | Diacylglycerol Acyltransferase Inhibitors | DGAT2, DGAT1, LCAT | NAMPT 291/4885DGAT1 2/4885EPHX2 735/4885 |
| US-20090099201-A1 | Diacylglycerol Acyltransferase Inhibitors | DGAT2, DGAT1, LCAT | NAMPT 291/4885DGAT1 2/4885EPHX2 735/4885 |
| US-20090105273-A1 | Diacylglycerol Acyltransferase Inhibitors | DGAT2, DGAT1, LCAT | NAMPT 291/4885DGAT1 2/4885EPHX2 735/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.