Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 6/20 | 0.38 |
| ▸ | KDR | P35968 | 5/20 | 0.38 |
| ▸ | RET | P07949 | 2/20 | 0.38 |
| ▸ | KIF5B | P33176 | 2/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 11/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.36 |
| ▸ | FLT1 | P17948 | 4/20 | 0.36 |
| ▸ | FLT4 | P35916 | 4/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.35 |
| ▸ | KIT | P10721 | 2/20 | 0.35 |
| ▸ | TEK | Q02763 | 2/20 | 0.35 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | CIT | O14578 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13063826 | 0.92 | EGFR (0.38) | ALOX15TSHREGFRKDRRET | |
| SCHEMBL13063605 | 0.91 | ALOX15 (0.42) | ALOX15TSHREGFRKDRRET | |
| SCHEMBL13063846 | 0.89 | MAP2K1 (0.41) | MAP2K1FLT1MAP2K2MAP2K5 | |
| SCHEMBL3807030 | 0.89 | ALOX15 (0.41) | ALOX15TSHREGFRKDRRET | |
| SCHEMBL3808578 | 0.85 | ALOX15 (0.39) | ALOX15TSHREGFRKDRRET | |
| SCHEMBL3806191 | 0.81 | MAP2K1 (0.48) | ALOX15TSHREGFRKDRRET | |
| SCHEMBL13063541 | 0.81 | ALOX15 (0.40) | ALOX15TSHREGFRKDRRET | |
| SCHEMBL3809218 | 0.81 | ALOX15 (0.42) | ALOX15TSHREGFRKDRRET | |
| SCHEMBL3806994 | 0.81 | MAP2K1 (0.42) | MAP2K1FLT1MAP2K2KITMAP2K5 | |
| SCHEMBL13063542 | 0.81 | SRC (0.36) | MAP2K1MAP2K2SRCBRAFBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010145197-A1 | NOVEL 6-ARYLAMINO PYRIDONE SULFONAMIDES AND 6-ARYLAMINO PYRAZINONE SULFONAMDIES AS MEK INHIBITORS | CHEMIZON (BEIJING), LTD. (CN) | 2010-12-23 | — | — | WO | disclosed |
| WO-2010145197-A1 | NOVEL 6-ARYLAMINO PYRIDONE SULFONAMIDES AND 6-ARYLAMINO PYRAZINONE SULFONAMDIES AS MEK INHIBITORS | CHEMIZON (BEIJING), LTD. (CN) | 2010-12-23 | — | — | WO | disclosed |