Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | TAS2R14 | Q9NYV8 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.31 |
| ▸ | CCR5 | P51681 | 4/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4804462 | 0.90 | CACNA1G (0.43) | OPRM1TACR1CACNA1GCACNA1HALDH1A1 | |
| SCHEMBL4804476 | 0.78 | CACNA1G (0.43) | OPRM1TACR1CACNA1GCACNA1HALDH1A1 | |
| SCHEMBL4804471 | 0.78 | CACNA1G (0.43) | OPRM1TACR1CACNA1GCACNA1HALDH1A1 | |
| SCHEMBL3806319 | 0.77 | CHRM5 (0.36) | MAPK1ALDH1A1KMT2ACYP3A4TAS2R14 | |
| SCHEMBL4675598 | 0.76 | CYP3A4 (0.40) | OPRM1CACNA1GCACNA1HCYP3A4CYP2D6 | |
| SCHEMBL3665336 | 0.75 | CHRM5 (0.36) | CACNA1GCACNA1HC5AR1 | |
| SCHEMBL3670916 | 0.75 | CHRM2 (0.38) | OPRM1CACNA1GCACNA1HALDH1A1LMNA | |
| SCHEMBL3665332 | 0.74 | POLB (0.35) | OPRM1CACNA1GCACNA1HALDH1A1OPRL1 | |
| SCHEMBL4804451 | 0.74 | CACNA1G (0.43) | OPRM1TACR1CACNA1GCACNA1HALDH1A1 | |
| SCHEMBL4681959 | 0.73 | OPRL1 (0.44) | OPRM1CACNA1GCACNA1HCYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155676-A2 | COMPOUNDS WITH ANTIPARASITIC ACTIVITY, APPLICATIONS THEREOF TO THE TREATMENT OF INFECTIOUS DISEASES CAUSED BY APICOMPLEXANS | Commissariat à l'Energie Atomique (FR) | 2010-02-24 | — | — | EP | claimed |
| WO-2008146172-A2 | COMPOUNDS WITH ANTIPARASITIC ACTIVITY, APPLICATIONS THEREOF TO THE TREATMENT OF INFECTIOUS DISEASES CAUSED BY APICOMPLEXANS | COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) | 2008-12-04 | — | — | WO | claimed |