Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 19/20 | 0.42 |
| ▸ | MAP2K2 | P36507 | 4/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.41 |
| ▸ | ADCK1 | Q86TW2 | 1/20 | 0.41 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.41 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.36 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13063528 | 0.97 | MAP2K1 (0.42) | MAP2K1MAP2K2CHEK1MAPK10PRKAG1 | |
| SCHEMBL3807711 | 0.97 | MAP2K1 (0.43) | MAP2K1MAP2K2CHEK1MAPK10PRKAG1 | |
| SCHEMBL3804101 | 0.86 | MAP2K1 (0.40) | MAP2K1MAP2K2CHEK1MAPK10PRKAG1 | |
| SCHEMBL3804823 | 0.86 | ADRA2A (0.36) | MAP2K1MAP2K2CHEK1MAPK10PRKAG1 | |
| SCHEMBL13063541 | 0.86 | ALOX15 (0.40) | MAP2K1MAP2K2MAP2K5FLT1 | |
| SCHEMBL13063568 | 0.85 | MAP2K1 (0.46) | MAP2K1MAP2K2CHEK1MAPK10PRKAG1 | |
| SCHEMBL3808230 | 0.85 | MAP2K1 (0.43) | MAP2K1MAP2K2CHEK1MAPK10PRKAG1 | |
| SCHEMBL13063529 | 0.84 | MAP2K1 (0.44) | MAP2K1MAP2K2CHEK1MAPK10PRKAG1 | |
| SCHEMBL13063564 | 0.84 | MAP2K1 (0.39) | MAP2K1MAP2K2CHEK1MAPK10PRKAG1 | |
| SCHEMBL13063784 | 0.84 | MAP2K1 (0.39) | MAP2K1MAP2K2CHEK1MAPK10PRKAG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010145197-A1 | NOVEL 6-ARYLAMINO PYRIDONE SULFONAMIDES AND 6-ARYLAMINO PYRAZINONE SULFONAMDIES AS MEK INHIBITORS | CHEMIZON (BEIJING), LTD. (CN) | 2010-12-23 | — | — | WO | disclosed |