Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 9/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TERT | O14746 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2469931 | 0.88 | SMN1; SMN2 (0.42) | MAPTSMN1; SMN2LIN28ATDP1TERT | |
| SCHEMBL13388472 | 0.87 | SMN1; SMN2 (0.46) | CXCR4CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL19889254 | 0.87 | MAPT (0.58) | MAPTSMN1; SMN2LIN28ATDP1TERT | |
| SCHEMBL3927566 | 0.85 | CXCR4 (0.47) | CXCR4CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL2476921 | 0.85 | CYP3A4 (0.42) | CXCR4MAPTSMN1; SMN2LIN28ATDP1 | |
| SCHEMBL2474014 | 0.84 | SLC1A5 (0.48) | MAPTSMN1; SMN2LIN28ATDP1CYP1A2 | |
| SCHEMBL2474008 | 0.84 | SLC1A5 (0.48) | MAPTSMN1; SMN2LIN28ATDP1CYP1A2 | |
| SCHEMBL3928577 | 0.84 | CXCR4 (0.47) | CXCR4CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL15834891 | 0.83 | MAPT (0.39) | MAPTSMN1; SMN2LIN28ATDP1TERT | |
| SCHEMBL20506840 | 0.83 | MAPT (0.49) | MAPTSMN1; SMN2LIN28ATDP1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090180951-A1 | INHIBITORS OF INTEGRIN VLA-4 | MOLECULAR INSIGHT PHARMACEUTICALS, INC. | 2009-07-16 | — | — | US | disclosed |
| US-20090180951-A1 | INHIBITORS OF INTEGRIN VLA-4 | MOLECULAR INSIGHT PHARMACEUTICALS, INC. | 2009-07-16 | — | — | US | disclosed |
| WO-2009076434-A1 | INHIBITORS OF INTEGRIN VLA-4 | MOLECULAR INSIGHT PHARMACEUTICALS, INC. (US) | 2009-06-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090180951-A1 | INHIBITORS OF INTEGRIN VLA-4 | ITGA1, ITGB1, ITGA4 | CXCR4 142/4885CHRM2 496/4885CHRM4 328/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.