Histidine

Histidine

SCHEMBL3811291

Cc1cc(=O)oc2cc(N)ccc12.N[C@@H](CCC(=O)O)C(=O)O.N[C@@H](Cc1c[nH]cn1)C(=O)O

nearest known ligand 0.47

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 11/20 0.47
KDM4E B2RXH2 10/20 0.47
HPGD P15428 9/20 0.47
HSD17B10 Q99714 7/20 0.47
GLA P06280 4/20 0.47
GAA P10253 4/20 0.47
CA12 O43570 2/20 0.47
CASP1 P29466 2/20 0.47
CASP7 P55210 2/20 0.47
CA9 Q16790 2/20 0.47
CA1 P00915 1/20 0.47
KMT2A Q03164 2/20 0.39
MEN1 O00255 1/20 0.39
IGLV6-57 P01721 1/20 0.36
LMNA P02545 2/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
AR P10275 3/20 0.36
ALDH2 P05091 1/20 0.35
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Histidine SCHEMBL4188611 0.94 ALDH1A1 (0.53) ALDH1A1KDM4EHPGDHSD17B10GLA
Histidine SCHEMBL27913920 0.94 ALDH1A1 (0.53) ALDH1A1KDM4EHPGDHSD17B10GLA
D-Glutamate SCHEMBL28805166 0.86 ALDH1A1 (0.63) ALDH1A1KDM4EHPGDHSD17B10GLA
Glutamine SCHEMBL6427499 0.79 ALDH1A1 (0.61) ALDH1A1KDM4EHPGDHSD17B10GLA
Glutamine SCHEMBL26967759 0.79 ALDH1A1 (0.61) ALDH1A1KDM4EHPGDHSD17B10GLA
Glutamine SCHEMBL4184505 0.78 ALDH1A1 (0.60) ALDH1A1KDM4EHPGDHSD17B10GLA
Histidine SCHEMBL23306565 0.78 CYP1A2 (0.51) KMT2ACYP1A2
Histidine SCHEMBL2228115 0.78 CYP1A2 (0.51) KMT2ACYP1A2
Histidine SCHEMBL19209941 0.78 CYP1A2 (0.51) KMT2ACYP1A2
Histidine SCHEMBL4356748 0.78 CYP1A2 (0.51) KMT2ACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009105662-A9 METHODS AND SYSTEMS FOR TREATING CELL PROLIFERATION DISORDERS USING PLASMONICS ENHANCED PHOTOSPECTRAL THERAPY (PEPST) AND EXCITON-PLASMON ENHANCED PHOTOTHERAPY (EPEP) IMMUNOLIGHT, LLC. (US) 2009-10-29 WO disclosed
WO-2009105662-A1 METHODS AND SYSTEMS FOR TREATING CELL PROLIFERATION DISORDERS USING PLASMONICS ENHANCED PHOTOSPECTRAL THERAPY (PEPST) AND EXCITON-PLASMON ENHANCED PHOTOTHERAPY (EPEP) IMMUNOLIGHT, LLC. (US) 2009-08-27 WO disclosed