Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.48 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4942930 | 0.87 | HRH3 (0.67) | HRH3GPR119USP30 | |
| SCHEMBL4942926 | 0.87 | HRH3 (0.67) | HRH3GPR119USP30 | |
| SCHEMBL3728196 | 0.83 | GPR119 (0.68) | HRH3GPR119USP30JAK2JAK1 | |
| SCHEMBL3720376 | 0.83 | GPR119 (0.68) | HRH3GPR119USP30JAK2JAK1 | |
| SCHEMBL4943963 | 0.83 | HRH3 (0.64) | HRH3GPR119USP30 | |
| SCHEMBL3725304 | 0.80 | ALDH1A1 (0.52) | HRH3GPR119USP30 | |
| SCHEMBL3725305 | 0.80 | ALDH1A1 (0.52) | HRH3GPR119USP30 | |
| SCHEMBL3674391 | 0.79 | HDAC6 (0.54) | HRH3GPR119USP30 | |
| SCHEMBL4943304 | 0.79 | HDAC6 (0.54) | HRH3GPR119USP30 | |
| SCHEMBL31142560 | 0.76 | USP30 (0.53) | GPR119USP30JAK2JAK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155719-A1 | AZACYCLYLBENZAMIDE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | Wyeth LLC (US) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008147945-A1 | AZACYCLYLBENZAMIDE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2008-12-04 | — | — | WO | disclosed |