Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | HSPB1 | P04792 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.43 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4845394 | 0.98 | TDP1 (0.53) | TDP1ATMRAB9ANPC1RECQL | |
| SCHEMBL3514013 | 0.84 | MAPT (0.53) | TDP1ATMRAB9ANPC1RECQL | |
| SCHEMBL2548000 | 0.84 | NPC1 (0.75) | TDP1ATMRAB9ANPC1RECQL | |
| SCHEMBL3533713 | 0.84 | RAB9A (0.51) | TDP1ATMRAB9ANPC1RECQL | |
| SCHEMBL1924834 | 0.84 | RAB9A (0.51) | TDP1ATMRAB9ANPC1RECQL | |
| SCHEMBL29382840 | 0.83 | NPC1 (0.54) | TDP1ATMRAB9ANPC1RECQL | |
| SCHEMBL3484477 | 0.83 | ALDH1A1 (0.52) | TDP1ATMRAB9ANPC1RECQL | |
| SCHEMBL10477058 | 0.83 | MAPT (0.52) | TDP1ATMRAB9ANPC1RECQL | |
| SCHEMBL2833379 | 0.83 | NPC1 (0.54) | TDP1ATMRAB9ANPC1RECQL | |
| SCHEMBL29960239 | 0.83 | TDP1 (0.51) | TDP1RAB9ANPC1RECQLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1885695-B8 | INDOLINE COMPOUNDS | FOURNIER LAB SA (FR) | 2009-08-12 | — | — | EP | disclosed |
| EP-1885695-B1 | INDOLINE COMPOUNDS | FOURNIER LAB SA (FR) | 2009-02-25 | — | — | EP | disclosed |
| EP-1885695-A2 | NOVEL INDOLINE COMPOUNDS | LABORATOIRES FOURNIER S.A. (FR) | 2008-02-13 | — | — | EP | disclosed |
| WO-2007000550-A2 | NOVEL INDOLINE COMPOUNDS | LABORATOIRES FOURNIER S.A. (FR) | 2007-01-04 | — | — | WO | disclosed |