Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HINT1 | P49773 | 7/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | GSK3A | P49840 | 2/20 | 0.61 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.61 |
| ▸ | PNP | P00491 | 1/20 | 0.58 |
| ▸ | NT5E | P21589 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.54 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.54 |
| ▸ | TGM2 | P21980 | 1/20 | 0.53 |
| ▸ | KRAS | P01116 | 5/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15061595 | 0.93 | HINT1 (0.67) | HINT1ALDH1A1GSK3ARPS6KA3MAPK14 | |
| SCHEMBL13296251 | 0.93 | ALDH1A1 (0.68) | HINT1ALDH1A1GSK3ARPS6KA3MAPK14 | |
| SCHEMBL3422978 | 0.93 | ALDH1A1 (0.68) | HINT1ALDH1A1GSK3ARPS6KA3MAPK14 | |
| SCHEMBL1120690 | 0.93 | ALDH1A1 (0.68) | HINT1ALDH1A1GSK3ARPS6KA3MAPK14 | |
| SCHEMBL1061031 | 0.93 | ALDH1A1 (0.68) | HINT1ALDH1A1GSK3ARPS6KA3MAPK14 | |
| SCHEMBL25407962 | 0.93 | ALDH1A1 (0.68) | HINT1ALDH1A1GSK3ARPS6KA3MAPK14 | |
| SCHEMBL278167 | 0.93 | ALDH1A1 (0.68) | HINT1ALDH1A1GSK3ARPS6KA3MAPK14 | |
| SCHEMBL14144174 | 0.93 | ALDH1A1 (0.68) | HINT1ALDH1A1GSK3ARPS6KA3MAPK14 | |
| SCHEMBL13462039 | 0.93 | ALDH1A1 (0.68) | HINT1ALDH1A1GSK3ARPS6KA3MAPK14 | |
| SCHEMBL4386265 | 0.93 | ALDH1A1 (0.68) | HINT1ALDH1A1GSK3ARPS6KA3MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2089409-A1 | COMPOUND HAVING INHIBITORY ACTIVITY ON A RHO-GTPASE CELL PROTEIN, A PROCESS FOR OBTAINING THE SAME, PHARMACEUTICAL COMPOSITIONS COMPRISION THEREOF AND A METHOD FOR THE TREATMENT OF A RHO-GTPASE CELL PROTEIN-MEDIATED CONDITION | Universidad Nacional De Quilmes (AR) | 2009-08-19 | — | — | EP | claimed |
| WO-2008055875-A1 | COMPOUND HAVING INHIBITORY ACTIVITY ON A RHO-GTPASE CELL PROTEIN, A PROCESS FOR OBTAINING THE SAME, PHARMACEUTICAL COMPOSITIONS COMPRISION THEREOF AND A METHOD FOR THE TREATMENT OF A RHO-GTPASE CELL PROTEIN-MEDIATED CONDITION | UNIVERSIDAD NACIONAL DE QUILMES (AR) | 2008-05-15 | — | — | WO | claimed |