SCHEMBL3812253

SCHEMBL3812253

C1CCC(CNC2CCNC2)CC1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 1/20 0.53
DPP4 P27487 1/20 0.40
FAP Q12884 1/20 0.40
DPP8 Q6V1X1 1/20 0.40
DPP9 Q86TI2 1/20 0.40
SLC6A2 P23975 1/20 0.37
SLC6A4 P31645 1/20 0.37
SLC6A3 Q01959 1/20 0.37
EPHX1 P07099 3/20 0.37
CHRM2 P08172 1/20 0.37
CHRM4 P08173 1/20 0.37
CHRM5 P08912 1/20 0.37
ADRA2B P18089 1/20 0.37
ADRA2C P18825 1/20 0.37
ADH1B P00325 1/20 0.36
ADH1C P00326 1/20 0.36
ADH1A P07327 1/20 0.36
ADH4 P08319 1/20 0.36
ADH7 P40394 1/20 0.36
GLB1 P16278 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4635186 0.94 KCNH2 (0.55) KCNH2DPP4FAPDPP8DPP9
SCHEMBL17311122 0.90 KCNH2 (0.59) KCNH2DPP4FAPDPP8DPP9
SCHEMBL20576713 0.90 KCNH2 (0.59) KCNH2DPP4FAPDPP8DPP9
SCHEMBL2673338 0.88 EPHX1 (0.44) KCNH2EPHX1CHRM2CHRM4CHRM5
SCHEMBL3307772 0.85 GNAI3 (0.41) KCNH2EPHX1CHRM2CHRM4CHRM5
SCHEMBL31014239 0.84 KCNH2 (0.44) KCNH2DPP4FAPDPP8DPP9
SCHEMBL31014227 0.84 KCNH2 (0.44) KCNH2DPP4FAPDPP8DPP9
SCHEMBL31014224 0.82 KCNH2 (0.45) KCNH2DPP4FAPDPP8DPP9
SCHEMBL27804953 0.81 GNAI3 (0.41) KCNH2EPHX1ADH1BADH1CADH1A
Hydrochloric Acid SCHEMBL28866192 0.80 KCNH2 (0.44) KCNH2DPP4FAPDPP8DPP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2089354-A1 NAPHTHALENYLOXYPROPENYL DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME Korea Research Institute Of Chemical Technology (KR) 2009-08-19 EP disclosed
WO-2008054154-A1 NAPHTHALENYLOXYPROPENYL DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2008-05-08 WO disclosed