Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | FAP | Q12884 | 1/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 6/20 | 0.35 |
| ▸ | MAOB | P27338 | 5/20 | 0.35 |
| ▸ | MAOA | P21397 | 3/20 | 0.33 |
| ▸ | ADH1B | P00325 | 1/20 | 0.33 |
| ▸ | ADH1C | P00326 | 1/20 | 0.33 |
| ▸ | ADH1A | P07327 | 1/20 | 0.33 |
| ▸ | ADH4 | P08319 | 1/20 | 0.33 |
| ▸ | ADH7 | P40394 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.32 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.32 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3812253 | 0.94 | KCNH2 (0.53) | KCNH2DPP4FAPDPP8DPP9 | |
| SCHEMBL20576713 | 0.91 | KCNH2 (0.59) | KCNH2DPP4FAPDPP8DPP9 | |
| SCHEMBL17311122 | 0.91 | KCNH2 (0.59) | KCNH2DPP4FAPDPP8DPP9 | |
| SCHEMBL31014239 | 0.90 | KCNH2 (0.44) | KCNH2DPP4FAPDPP8DPP9 | |
| SCHEMBL31014227 | 0.90 | KCNH2 (0.44) | KCNH2DPP4FAPDPP8DPP9 | |
| SCHEMBL27804953 | 0.87 | GNAI3 (0.41) | KCNH2KDM1AMAOBMAOAADH1B | |
| SCHEMBL28063709 | 0.85 | ADH1B (0.37) | KCNH2KDM1AMAOBADH1BADH1C | |
| SCHEMBL31014224 | 0.83 | KCNH2 (0.45) | KCNH2DPP4FAPDPP8DPP9 | |
| SCHEMBL3307772 | 0.83 | GNAI3 (0.41) | KCNH2KDM1AMAOBMAOAADH1B | |
| Hydrochloric Acid SCHEMBL28254730 | 0.83 | ADH1B (0.35) | KCNH2KDM1AMAOBADH1BADH1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638933-B1 | N-PYRROLIDIN-3-YL-AMIDE DERIVATIVES AS SEROTONIN AND NORADRENALINE RE-UPTAKE INHIBITORS | PFIZER LTD (GB) | 2008-06-11 | — | — | EP | claimed |