Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.46 |
| ▸ | RAB9A | P51151 | 8/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3817576 | 0.84 | RAB9A (0.47) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL3813291 | 0.82 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2MAPTNFKB1 | |
| SCHEMBL28747879 | 0.82 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2MAPTNFKB1 | |
| SCHEMBL3817533 | 0.79 | MAPT (0.40) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL28747882 | 0.77 | MAPT (0.41) | NPC1RAB9ASMN1; SMN2MAPTNFKB1 | |
| SCHEMBL3807930 | 0.73 | TSHR (0.40) | NPC1RAB9ASMN1; SMN2MAPTNFKB1 | |
| SCHEMBL3810184 | 0.67 | MAPT (0.40) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL3808032 | 0.66 | TSHR (0.43) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL27577725 | 0.66 | KMT2A (0.36) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL3809724 | 0.65 | TSHR (0.47) | NPC1RAB9ASMN1; SMN2MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341786-B9 | SUBSTITUTED DERIVATIVES OF AMINOFURAN-2-YL-ACETIC ACID AND AMINOTHIEN-2-YL-ACETIC ACID AND THE USE THEREOF FOR TREATING MIGRAINES AND PAIN | GRUENENTHAL GMBH (DE) | 2009-08-05 | — | — | EP | claimed |
| EP-1341786-B1 | SUBSTITUTED DERIVATIVES OF AMINOFURAN-2-YL-ACETIC ACID AND AMINOTHIEN-2-YL-ACETIC ACID AND THE USE THEREOF FOR TREATING MIGRAINES AND PAIN | GRUENENTHAL GMBH (DE) | 2008-12-24 | — | — | EP | claimed |