Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 4/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 3/20 | 0.37 |
| ▸ | HTR5A | P47898 | 2/20 | 0.37 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL336486 | 1.00 | AR (0.43) | ARHTR2CHTR2AESR1ESR2 | |
| SCHEMBL14943839 | 1.00 | AR (0.43) | ARHTR2CHTR2AESR1ESR2 | |
| SCHEMBL29644324 | 1.00 | AR (0.43) | ARHTR2CHTR2AESR1ESR2 | |
| Hydrochloric Acid SCHEMBL8597665 | 0.98 | AR (0.42) | ARHTR2CHTR2AESR1ESR2 | |
| SCHEMBL4102066 | 0.87 | HTR2C (0.44) | ARHTR2CHTR2AHTR1DHTR1B | |
| SCHEMBL29529402 | 0.81 | LMNA (0.46) | ARHTR2CHTR2AALDH1A1HTR5A | |
| SCHEMBL8937088 | 0.81 | LMNA (0.46) | ARHTR2CHTR2AALDH1A1HTR5A | |
| SCHEMBL30681298 | 0.81 | LMNA (0.46) | ARHTR2CHTR2AALDH1A1HTR5A | |
| SCHEMBL4133012 | 0.80 | AR (0.40) | ARESR1ESR2ALDH1A1HTR5A | |
| SCHEMBL13091374 | 0.80 | AR (0.40) | ARESR1ESR2ALDH1A1HTR5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086959-A1 | SUBSTITUTED 2-IMIDAZOLES AS MODULATORS OF THE TRACE AMINE ASSOCIATED RECEPTORS | F.HOFFMANN-LA ROCHE AG (CH) | 2009-08-12 | — | — | EP | disclosed |
| WO-2008052907-A1 | SUBSTITUTED 2-IMIDAZOLES AS MODULATORS OF THE TRACE AMINE ASSOCIATED RECEPTORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-05-08 | — | — | WO | disclosed |