Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | PROKR1 | Q8TCW9 | 3/20 | 0.35 |
| ▸ | RBP4 | P02753 | 4/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.33 |
| ▸ | SCD | O00767 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3811889 | 0.89 | GRM5 (0.38) | TP53RBP4HSD17B10ALDH1A1HPGD | |
| SCHEMBL3817198 | 0.88 | HRH4 (0.33) | TP53ALDH1A1SMN1; SMN2MEN1LMNA | |
| SCHEMBL3820148 | 0.88 | NOTUM (0.41) | TP53ALDH1A1HPGDMEN1LMNA | |
| SCHEMBL3819666 | 0.87 | GRM5 (0.36) | TP53ALDH1A1SMN1; SMN2MEN1LMNA | |
| SCHEMBL3818514 | 0.87 | DRD2 (0.38) | TP53PROKR1ALDH1A1HPGDMEN1 | |
| SCHEMBL929608 | 0.86 | GRM5 (0.44) | RBP4HSD17B10ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3815438 | 0.85 | NOTUM (0.43) | TP53PROKR1RBP4HSD17B10ALDH1A1 | |
| SCHEMBL3819257 | 0.84 | CYP1A2 (0.37) | TP53ALDH1A1HPGD | |
| SCHEMBL3812729 | 0.83 | CCKBR (0.33) | TP53ALDH1A1MEN1LMNAMAPK1 | |
| SCHEMBL3820713 | 0.83 | MAPT (0.39) | TP53ALDH1A1LMNAHRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | claimed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |