Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.96 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.96 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.78 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.69 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.59 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 1/20 | 0.56 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1276590 | 0.98 | ALDH1A1 (1.00) | ALDH1A1KDM4EHRH3HRH4SIGMAR1 | |
| SCHEMBL11227514 | 0.98 | ALDH1A1 (1.00) | ALDH1A1KDM4EHRH3HRH4SIGMAR1 | |
| Hydrochloric Acid SCHEMBL7405362 | 0.96 | ALDH1A1 (0.96) | ALDH1A1KDM4EHRH3HRH4SIGMAR1 | |
| SCHEMBL7937990 | 0.96 | ALDH1A1 (0.95) | ALDH1A1KDM4EHRH3HRH4SIGMAR1 | |
| Hydrochloric Acid SCHEMBL7281619 | 0.93 | ALDH1A1 (0.91) | ALDH1A1KDM4EHRH3HRH4SIGMAR1 | |
| SCHEMBL11610713 | 0.92 | ALDH1A1 (0.88) | ALDH1A1KDM4EHRH3HRH4SIGMAR1 | |
| Ammonia Solution, Strong SCHEMBL2924519 | 0.92 | ALDH1A1 (0.81) | ALDH1A1KDM4EHRH3HRH4SIGMAR1 | |
| SCHEMBL23851111 | 0.91 | ALDH1A1 (0.87) | ALDH1A1KDM4EHRH3HRH4SIGMAR1 | |
| SCHEMBL4277270 | 0.89 | HRH3 (1.00) | ALDH1A1KDM4EHRH3HRH4POLB | |
| Hydrochloric Acid SCHEMBL7468055 | 0.86 | HRH3 (0.95) | ALDH1A1KDM4EHRH3HRH4POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090306141-A1 | Novel Compounds | ASTRAZENECA AB (SE) | 2009-12-10 | — | — | US | disclosed |
| US-7528156-B2 | Compounds | ASTRAZENECA AB (SE) | 2009-05-05 | — | — | US | disclosed |
| US-6911458-B2 | Compounds | ASTRA ZENECA (SE) | 2005-06-28 | — | — | US | disclosed |
| US-20050090494-A1 | Novel compounds | ASTRAZENECA AB, A SWEDEN CORPORATION | 2005-04-28 | — | — | US | disclosed |
| US-20030162772-A1 | Novel compounds | ASTRAZENECA AB (SE) | 2003-08-28 | — | — | US | disclosed |
| EP-1299357-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2003-04-09 | — | — | EP | disclosed |
| WO-2001098273-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2001-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306141-A1 | Novel Compounds | CHRM2, CHRM1, C1R | ALDH1A1 1779/4885KDM4E 1451/4885HRH3 491/4885 |
| US-20050090494-A1 | Novel compounds | CHRM2, CHRM1, C1R | ALDH1A1 1779/4885KDM4E 1451/4885HRH3 491/4885 |
| US-20030162772-A1 | Novel compounds | RPS4X, RPS4Y1, MRPS18A | ALDH1A1 949/4885KDM4E 1288/4885HRH3 2166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.