Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3813984 | 0.92 | EGFR (0.41) | KMT2AALDH1A1MAPTCYP3A4CYP2C9 | |
| SCHEMBL3810513 | 0.83 | ELANE (0.46) | ALDH1A1MAPTCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL4175500 | 0.77 | ELANE (0.48) | KMT2AALDH1A1MAPTCYP3A4CYP2C9 | |
| SCHEMBL22147873 | 0.74 | ALDH1A1 (0.42) | KMT2AALDH1A1MAPTCYP3A4CYP2C9 | |
| SCHEMBL3810507 | 0.74 | ELANE (0.45) | KMT2AALDH1A1MAPTCYP3A4CYP2C9 | |
| SCHEMBL30977391 | 0.72 | EPHB3 (0.56) | KMT2AALDH1A1MAPTF2PLAU | |
| SCHEMBL23389792 | 0.70 | TGFBR1 (0.39) | KMT2A | |
| SCHEMBL29796646 | 0.70 | TGFBR1 (0.39) | KMT2A | |
| SCHEMBL3694473 | 0.70 | ALDH1A1 (0.46) | KMT2AALDH1A1MAPTCYP3A4CYP2C9 | |
| SCHEMBL24369876 | 0.68 | EPHB3 (0.58) | ALDH1A1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |