Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.37 |
| ▸ | RAB9A | P51151 | 8/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 7/20 | 0.35 |
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.35 |
| ▸ | RELA | Q04206 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.34 |
| ▸ | MEN1 | O00255 | 7/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | STAT1 | P42224 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27850551 | 0.86 | SMN1; SMN2 (0.36) | NPC1SMN1; SMN2RAB9AHTTALOX15 | |
| SCHEMBL381118 | 0.80 | NPC1 (0.42) | NPC1SMN1; SMN2RAB9AHTTALOX15 | |
| SCHEMBL381373 | 0.79 | CSNK2A2 (0.33) | NPC1SMN1; SMN2HPGDKMT2AMEN1 | |
| SCHEMBL23682701 | 0.74 | ALOX15 (0.46) | NPC1SMN1; SMN2RAB9AHTTALOX15 | |
| SCHEMBL381758 | 0.74 | CSNK2A2 (0.37) | NPC1SMN1; SMN2RAB9AHPGDALDH1A1 | |
| SCHEMBL23815870 | 0.70 | RAB9A (0.42) | NPC1SMN1; SMN2RAB9AHTTALOX15 | |
| SCHEMBL26241956 | 0.69 | RAB9A (0.42) | NPC1SMN1; SMN2RAB9AHTTALOX15 | |
| SCHEMBL381273 | 0.66 | GBA1 (0.34) | — | |
| SCHEMBL380174 | 0.66 | NPC1 (0.38) | NPC1SMN1; SMN2RAB9AHTTALOX15 | |
| SCHEMBL381374 | 0.66 | TSHR (0.36) | HTTHPGDMAPTALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476253-B2 | Amide derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-07-02 | — | — | US | disclosed |
| US-20120071467-A1 | AMIDE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-03-22 | — | — | US | disclosed |
| EP-2409977-A1 | AMIDE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2012-01-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071467-A1 | AMIDE DERIVATIVE | CHRM3, CHRM2, TACR2 | NPC1 1488/4885SMN1; SMN2 1907/4885RAB9A 3525/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.