SCHEMBL3815684

SCHEMBL3815684

CC(C)(C)OC(=O)NCCCNc1nc(Cl)ccc1[N+](=O)[O-]

nearest known ligand 0.56

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
STK17B O94768 1/20 0.56
STK17A Q9UEE5 1/20 0.56
MAPT P10636 3/20 0.55
BRD4 O60885 13/20 0.49
HTT P42858 1/20 0.46
SIRT5 Q9NXA8 2/20 0.45
LMNA P02545 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3813745 0.93 MAPT (0.57) STK17BSTK17AMAPTBRD4HTT
SCHEMBL3410303 0.87 STK17B (0.49) STK17BSTK17ABRD4SIRT5LMNA
SCHEMBL29802555 0.85 STK17A (0.72) STK17BSTK17ABRD4SIRT5
SCHEMBL3812414 0.83 MAPT (0.44) STK17BSTK17AMAPTBRD4LMNA
SCHEMBL20278061 0.82 CA12 (0.47) STK17BSTK17AMAPTBRD4HTT
SCHEMBL8290003 0.82 LMNA (0.64) STK17BSTK17AMAPTBRD4LMNA
SCHEMBL3815624 0.82 STK17B (0.45) STK17BSTK17ABRD4SIRT5LMNA
SCHEMBL3815680 0.80 MAPT (0.55) STK17AMAPTHTTSIRT5LMNA
SCHEMBL3408429 0.80 TXNRD1 (0.47) STK17BSTK17AMAPTBRD4LMNA
SCHEMBL8041119 0.80 STK17B (0.46) STK17BSTK17AMAPTBRD4SIRT5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1615925-B1 IMIDAZOPYRIDINE DERIVATIVES AS MELANOCORTIN RECEPTOR AGONISTS IPSEN PHARMA (FR) 2009-05-27 EP disclosed
US-7495009-B2 Imidazopyridine derivatives as melancortin receptor agonists SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) 2009-02-24 US disclosed
US-20060173036-A1 Imidazopyridine derivatives as melanocortin receptor agonists SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S) (FR) 2006-08-03 US disclosed
EP-1615925-A1 IMIDAZOPYRIDINE DERIVATIVES AS MELANOCORTIN RECEPTOR AGONISTS Société de Conseils de Recherches et d'Applications Scientifiques ( S.C.R.A.S.) (FR) 2006-01-18 EP disclosed
WO-2004089951-A1 IMIDAZOPYRIDINE DERIVATIVES HAVING AN AFFINITY FOR MELANOCORTIN RECEPTORS SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) 2004-10-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060173036-A1 Imidazopyridine derivatives as melanocortin receptor agonists MC4R, MC1R, MC3R STK17B 1802/4885STK17A 1557/4885MAPT 2117/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.