Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 15/20 | 0.47 |
| ▸ | TACR3 | P29371 | 5/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3815725 | 0.89 | P2RX7 (0.41) | P2RX7TACR3KCNH2 | |
| SCHEMBL3812459 | 0.88 | P2RX7 (0.51) | P2RX7TACR3 | |
| SCHEMBL3819578 | 0.86 | P2RX7 (0.47) | P2RX7TACR3KCNH2 | |
| SCHEMBL929961 | 0.85 | GRM5 (0.49) | P2RX7TACR3 | |
| SCHEMBL3810732 | 0.84 | TACR3 (0.47) | P2RX7TACR3KCNH2 | |
| SCHEMBL3814566 | 0.83 | P2RX7 (0.48) | P2RX7TACR3KCNH2 | |
| SCHEMBL3817212 | 0.83 | ALDH1A1 (0.33) | P2RX7 | |
| SCHEMBL3815490 | 0.83 | P2RX7 (0.45) | P2RX7TACR3KCNH2 | |
| SCHEMBL3815389 | 0.83 | P2RX7 (0.54) | P2RX7TACR3 | |
| SCHEMBL3819173 | 0.82 | P2RX7 (0.50) | P2RX7TACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | claimed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |