Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | BUB1 | O43683 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NAAA | Q02083 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3832995 | 0.84 | CTSL (0.39) | AGTR2CTSLCTSBCTSKBUB1 | |
| SCHEMBL5788946 | 0.81 | CTSL (0.41) | AGTR2CTSLCTSBCTSKBUB1 | |
| SCHEMBL600214 | 0.74 | CYP3A4 (0.42) | LMNA | |
| SCHEMBL3958422 | 0.74 | CYP3A4 (0.42) | LMNA | |
| SCHEMBL3953338 | 0.74 | CYP3A4 (0.42) | LMNA | |
| SCHEMBL22835922 | 0.74 | PDE4D (0.41) | AGTR2CTSLCTSBCTSKBUB1 | |
| SCHEMBL22835923 | 0.74 | PDE4D (0.41) | AGTR2CTSLCTSBCTSKBUB1 | |
| SCHEMBL599909 | 0.74 | TSHR (0.48) | AGTR2CTSLCTSBCTSKBUB1 | |
| SCHEMBL600663 | 0.74 | TSHR (0.48) | AGTR2CTSLCTSBCTSKBUB1 | |
| SCHEMBL22835948 | 0.73 | MGLL (0.38) | AGTR2CTSLCTSBCTSKBUB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828145-A4 | 2' AND 3' - SUBSTITUTED CYCLOBUTYL NUCLEOSIDE ANALOGS FOR THE TREATMENT OF VIRAL INFECTIONS AND ABNORMAL CELLULAR PROLIFERATION | UNIV EMORY (US) | 2009-08-19 | — | — | EP | disclosed |
| EP-1828145-A2 | 2' AND 3' - SUBSTITUTED CYCLOBUTYL NUCLEOSIDE ANALOGS FOR THE TREATMENT OF VIRAL INFECTIONS AND ABNORMAL CELLULAR PROLIFERATION | EMORY UNIVERSITY (US) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006063281-A2 | 2' AND 3' - SUBSTITUTED CYCLOBUTYL NUCLEOSIDE ANALOGS FOR THE TREATMENT OF VIRAL INFECTIONS AND ABNORMAL CELLULAR PROLIFERATION | EMORY UNIVERSITY (US) | 2006-06-15 | — | — | WO | disclosed |