Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CCR5 | P51681 | 10/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3764215 | 0.89 | CYP3A4 (0.45) | CYP3A4CCR5LMNATP53MAPT | |
| SCHEMBL3759966 | 0.81 | CCR5 (0.40) | CCR5 | |
| SCHEMBL3757285 | 0.81 | IDO1 (0.44) | CCR5L3MBTL1 | |
| SCHEMBL3757286 | 0.81 | IDO1 (0.44) | CCR5L3MBTL1 | |
| SCHEMBL3757466 | 0.79 | CCR5 (0.41) | CCR5KDM4D | |
| SCHEMBL3764142 | 0.77 | CCR5 (0.39) | CCR5KDM4D | |
| SCHEMBL3756604 | 0.77 | CCR5 (0.40) | CCR5KDM4D | |
| SCHEMBL3757008 | 0.76 | CCR5 (0.49) | CCR5 | |
| SCHEMBL3753538 | 0.76 | CCR5 (0.49) | CCR5 | |
| SCHEMBL3755280 | 0.73 | CARM1 (0.48) | CCR5TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1942890-A4 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | GENZYME CORP (US) | 2009-08-26 | — | — | EP | disclosed |
| EP-1942890-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | ANORMED INC. (CA) | 2008-07-16 | — | — | EP | disclosed |
| WO-2006138350-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | ANORMED INC. (CA) | 2006-12-28 | — | — | WO | disclosed |