Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 8/20 | 0.41 |
| ▸ | TACR2 | P21452 | 7/20 | 0.41 |
| ▸ | TACR1 | P25103 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | QRFPR | Q96P65 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3811233 | 0.94 | TACR3 (0.41) | TACR3TACR2TACR1MEN1KMT2A | |
| SCHEMBL3818196 | 0.90 | HTT (0.37) | TACR3TACR2TACR1MEN1KMT2A | |
| SCHEMBL1010196 | 0.86 | GRM5 (0.43) | TACR3TACR2TACR1MEN1KMT2A | |
| SCHEMBL3820118 | 0.86 | GAA (0.42) | MEN1KMT2ADRD1POLBMAPK1 | |
| SCHEMBL3813024 | 0.85 | TACR3 (0.40) | TACR3TACR2TACR1MEN1KMT2A | |
| SCHEMBL3819788 | 0.84 | MAPK1 (0.37) | TACR3TACR2TACR1MEN1KMT2A | |
| SCHEMBL3817657 | 0.84 | MCHR1 (0.40) | MEN1KMT2ADRD1POLBQRFPR | |
| SCHEMBL3816792 | 0.84 | TACR3 (0.40) | TACR3TACR2TACR1MEN1KMT2A | |
| SCHEMBL3811512 | 0.83 | DRD1 (0.35) | MEN1KMT2ADRD1POLBLMNA | |
| SCHEMBL3817877 | 0.83 | UCHL1 (0.40) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | claimed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |