Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 9/20 | 0.40 |
| ▸ | TACR2 | P21452 | 8/20 | 0.40 |
| ▸ | TACR1 | P25103 | 5/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3815249 | 0.90 | TACR3 (0.34) | TACR3TACR2TACR1MAPK1NPC1 | |
| SCHEMBL3813024 | 0.87 | TACR3 (0.40) | TACR3TACR2TACR1DRD1MEN1 | |
| SCHEMBL3821584 | 0.87 | ALDH1A1 (0.35) | MAPK1NPSR1NPC1RAB9AADORA2A | |
| SCHEMBL1010814 | 0.87 | GRM5 (0.42) | TACR3TACR2TACR1GRM5MAPT | |
| SCHEMBL3815643 | 0.85 | MAPT (0.38) | MAPK1NPSR1NPC1RAB9ADRD1 | |
| SCHEMBL3816728 | 0.84 | TACR3 (0.41) | TACR3TACR2TACR1MAPK1DRD1 | |
| SCHEMBL3820067 | 0.84 | DRD1 (0.42) | MAPK1NPSR1NPC1RAB9ADRD1 | |
| SCHEMBL3816184 | 0.83 | DRD1 (0.38) | DRD1GRM5 | |
| SCHEMBL3820974 | 0.83 | UCHL1 (0.39) | MAPK1NPSR1GRM5 | |
| SCHEMBL3816368 | 0.83 | KLKB1 (0.35) | DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | claimed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |