Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 19/20 | 0.40 |
| ▸ | TACR2 | P21452 | 7/20 | 0.39 |
| ▸ | TACR1 | P25103 | 5/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.38 |
| ▸ | ERG | P11308 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3822498 | 0.91 | TACR3 (0.39) | TACR3TACR2TACR1KCNH2ERG | |
| SCHEMBL3810556 | 0.88 | TACR3 (0.43) | TACR3TACR2TACR1KCNH2ERG | |
| SCHEMBL4185749 | 0.88 | TACR3 (0.37) | TACR3TACR2TACR1KCNH2ERG | |
| SCHEMBL3812475 | 0.88 | TACR3 (0.46) | TACR3TACR2TACR1KCNH2CYP1A2 | |
| SCHEMBL3815823 | 0.87 | TACR3 (0.42) | TACR3TACR2TACR1KCNH2ERG | |
| SCHEMBL3815789 | 0.85 | TACR3 (0.51) | TACR3TACR2TACR1KCNH2ERG | |
| SCHEMBL3819870 | 0.85 | TACR3 (0.43) | TACR3TACR2TACR1KCNH2ERG | |
| SCHEMBL3819604 | 0.85 | TACR3 (0.36) | TACR3TACR2TACR1KCNH2ERG | |
| SCHEMBL3811664 | 0.85 | TACR3 (0.43) | TACR3TACR2TACR1KCNH2ERG | |
| SCHEMBL3813972 | 0.85 | ALDH1A1 (0.36) | TACR3TACR2TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | claimed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |