Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 9/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GRM5 | P41594 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TACR3 | P29371 | 2/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3815154 | 0.90 | ALDH1A1 (0.38) | P2RX7ALDH1A1GRM5KDM4ENPC1 | |
| SCHEMBL929504 | 0.87 | GRM5 (0.47) | P2RX7ALDH1A1GRM5KDM4ETSHR | |
| SCHEMBL3810587 | 0.83 | P2RX7 (0.46) | P2RX7 | |
| SCHEMBL3816876 | 0.83 | P2RX7 (0.50) | P2RX7TACR3 | |
| SCHEMBL3820174 | 0.82 | P2RX7 (0.42) | P2RX7ALDH1A1GRM5KDM4ENPC1 | |
| SCHEMBL3822949 | 0.81 | P2RX7 (0.33) | P2RX7ALDH1A1GRM5TACR3 | |
| SCHEMBL930490 | 0.80 | ALDH1A1 (0.54) | ALDH1A1GRM5TSHR | |
| SCHEMBL3815558 | 0.79 | P2RX7 (0.53) | P2RX7ALDH1A1GRM5KDM4ENPC1 | |
| SCHEMBL3810702 | 0.77 | SCD (0.50) | P2RX7ALDH1A1GRM5KDM4ENPC1 | |
| SCHEMBL3816866 | 0.76 | NAMPT (0.44) | P2RX7ALDH1A1GRM5KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | claimed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |