Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | CTSC | P53634 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.47 |
| ▸ | ALPI | P09923 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | XIAP | P98170 | 1/20 | 0.45 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.45 |
| ▸ | MME | P08473 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | GPR142 | Q7Z601 | 2/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27677789 | 1.00 | L3MBTL1 (0.54) | L3MBTL1CTSCTP53MAPK1POLB | |
| SCHEMBL28767638 | 1.00 | L3MBTL1 (0.54) | L3MBTL1CTSCTP53MAPK1POLB | |
| SCHEMBL27677872 | 0.89 | L3MBTL1 (0.50) | L3MBTL1TP53MAPK1MMEGPR142 | |
| SCHEMBL27677869 | 0.89 | L3MBTL1 (0.50) | L3MBTL1TP53MAPK1MMEGPR142 | |
| SCHEMBL3813895 | 0.88 | NPC1 (0.49) | L3MBTL1CTSCTP53MAPK1SLC15A1 | |
| SCHEMBL3816209 | 0.88 | NPC1 (0.49) | L3MBTL1CTSCTP53MAPK1SLC15A1 | |
| SCHEMBL3813898 | 0.88 | NPC1 (0.49) | L3MBTL1CTSCTP53MAPK1SLC15A1 | |
| SCHEMBL27696375 | 0.87 | ROCK2 (0.52) | L3MBTL1MMP1MMP2MMP9MMP13 | |
| SCHEMBL27696373 | 0.87 | ROCK2 (0.52) | L3MBTL1MMP1MMP2MMP9MMP13 | |
| SCHEMBL28767617 | 0.86 | L3MBTL1 (0.50) | L3MBTL1CTSCTP53MAPK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101023079-B | Substituted hydantoins for the treatment of cancer | HOFFMANN LA ROCHE | 2010-05-05 | — | — | CN | disclosed |
| EP-1791837-B1 | SUBSTITUTED HYDANTOINS FOR THE TREATMENT OF CANCER | HOFFMANN LA ROCHE (CH) | 2009-08-19 | — | — | EP | disclosed |
| CN-101023079-A | Substituted hydantoins for the treatment of cancer | HOFFMANN LA ROCHE (CH) | 2007-08-22 | — | — | CN | disclosed |