Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.73 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | PDE9A | O76083 | 1/20 | 0.43 |
| ▸ | PDE1A | P54750 | 1/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CTSV | O60911 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.36 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3492301 | 0.85 | PDE5A (1.00) | PDE5AMAPTPDE9APDE1APDE1B | |
| SCHEMBL38530 | 0.85 | PDE5A (0.73) | PDE5AMAPTPDE9APDE1APDE1B | |
| SCHEMBL38743 | 0.84 | PDE5A (0.82) | PDE5AMAPTPDE9APDE1APDE1B | |
| SCHEMBL38098 | 0.84 | PDE5A (0.56) | PDE5AMAPTPDE9APDE1APDE1B | |
| SCHEMBL4515609 | 0.80 | PDE5A (0.76) | PDE5AMAPTPDE9APDE1APDE1B | |
| SCHEMBL38463 | 0.78 | PDE5A (0.69) | PDE5AMAPTPDE9APDE1APDE1B | |
| SCHEMBL16175587 | 0.77 | PDE5A (0.74) | PDE5APDE9APDE1APDE1BPDE1C | |
| SCHEMBL38370 | 0.77 | PDE5A (0.70) | PDE5APDE9APDE1APDE1BPDE1C | |
| Meglumine SCHEMBL21459098 | 0.75 | PDE5A (0.74) | PDE5AMAPTPDE9APDE1APDE1B | |
| SCHEMBL37888 | 0.74 | PDE5A (0.63) | PDE5APDE9APDE1APDE1BPDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012004900-A1 | THIENOPYRIMIDINE COMPOUNDS | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2012-01-12 | — | — | WO | disclosed |