Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.82 |
| ▸ | PDE9A | O76083 | 1/20 | 0.45 |
| ▸ | PDE1A | P54750 | 1/20 | 0.45 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.45 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.45 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.41 |
| ▸ | SELE | P16581 | 1/20 | 0.41 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | PNP | P00491 | 1/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3492301 | 0.90 | PDE5A (1.00) | PDE5APDE9APDE1APDE1BPDE1C | |
| SCHEMBL4515609 | 0.85 | PDE5A (0.76) | PDE5APDE9APDE1APDE1BPDE1C | |
| SCHEMBL38176 | 0.84 | PDE5A (0.73) | PDE5APDE9APDE1APDE1BPDE1C | |
| SCHEMBL37864 | 0.83 | PDE5A (0.82) | PDE5APDE9APDE1APDE1BPDE1C | |
| SCHEMBL37776 | 0.82 | PDE5A (0.61) | PDE5APDE9APDE1APDE1BPDE1C | |
| SCHEMBL16175587 | 0.82 | PDE5A (0.74) | PDE5APDE9APDE1APDE1BPDE1C | |
| SCHEMBL38370 | 0.81 | PDE5A (0.70) | PDE5APDE9APDE1APDE1BPDE1C | |
| SCHEMBL37554 | 0.80 | PDE5A (0.66) | PDE5APDE9APDE1APDE1BPDE1C | |
| SCHEMBL38463 | 0.80 | PDE5A (0.69) | PDE5APDE9APDE1APDE1BPDE1C | |
| SCHEMBL3494163 | 0.78 | PDE5A (0.79) | PDE5ASMN1; SMN2POLBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012004900-A1 | THIENOPYRIMIDINE COMPOUNDS | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2012-01-12 | — | — | WO | disclosed |