Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 6/20 | 0.32 |
| ▸ | CDK11A | Q9UQ88 | 1/20 | 0.32 |
| ▸ | INSR | P06213 | 1/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 4/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.30 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.30 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.30 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.30 |
| ▸ | DHODH | Q02127 | 2/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.30 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.30 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.30 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1987005 | 0.91 | SRC (0.33) | SRCCDK11AINSRALKDGAT1 | |
| SCHEMBL1987643 | 0.89 | INSR (0.35) | SRCCDK11AINSRALKDGAT1 | |
| SCHEMBL3813188 | 0.84 | ALK (0.36) | INSRALKBTKFGFR1AURKA | |
| SCHEMBL1987008 | 0.83 | INSR (0.33) | SRCINSRALKBTKFGFR1 | |
| SCHEMBL1986383 | 0.81 | SIRT6 (0.39) | SRCCDK11ADGAT1AURKAFLT3 | |
| SCHEMBL1987647 | 0.80 | INSR (0.35) | INSRALKBTKFGFR1AURKA | |
| SCHEMBL1985484 | 0.79 | ALK (0.34) | INSRALKAURKAFLT3AURKB | |
| SCHEMBL3485255 | 0.77 | ALK (0.37) | INSRALKAURKAAURKBNTRK1 | |
| SCHEMBL1984180 | 0.75 | ALK (0.37) | INSRALKBTKFGFR1AURKA | |
| Hydrochloric Acid SCHEMBL1984175 | 0.75 | ALK (0.36) | INSRALKBTKFGFR1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2089394-A1 | SUBSTITUTED PYRROLO-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2009-08-19 | — | — | EP | disclosed |
| WO-2008043745-A1 | SUBSTITUTED PYRROLO-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2008-04-17 | — | — | WO | disclosed |