Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | IDH1 | O75874 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3813712 | 0.74 | KDM4E (0.69) | KDM4ERAB9ASMN1; SMN2LMNACYP19A1 | |
| SCHEMBL3815644 | 0.74 | RAB9A (0.54) | KDM4ERAB9ASMN1; SMN2LMNACYP19A1 | |
| SCHEMBL6646406 | 0.74 | KDM4E (0.61) | KDM4ERAB9ASMN1; SMN2LMNACYP19A1 | |
| SCHEMBL3814593 | 0.72 | KDM4E (0.66) | KDM4ERAB9ASMN1; SMN2LMNACYP19A1 | |
| SCHEMBL3823501 | 0.72 | RAB9A (0.54) | KDM4ERAB9ASMN1; SMN2LMNACYP19A1 | |
| SCHEMBL6647164 | 0.71 | KDM4E (0.59) | KDM4ERAB9ASMN1; SMN2LMNACYP19A1 | |
| SCHEMBL6648866 | 0.70 | KDM4E (0.56) | KDM4ERAB9ASMN1; SMN2LMNACYP19A1 | |
| SCHEMBL3824243 | 0.70 | KDM4E (0.58) | KDM4ERAB9ASMN1; SMN2LMNACYP19A1 | |
| SCHEMBL4283884 | 0.70 | KDM4E (1.00) | KDM4ERAB9ASMN1; SMN2LMNACYP19A1 | |
| SCHEMBL6786537 | 0.69 | KDM4E (0.61) | KDM4ERAB9ASMN1; SMN2LMNACYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1348706-B1 | SUBSTITUTED THIAZOLE DERIVATIVES BEARING 3-PYRIDYL GROUPS, PROCESS FOR PREPARING THE SAME AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2009-08-19 | — | — | EP | claimed |
| EP-1348706-B1 | SUBSTITUTED THIAZOLE DERIVATIVES BEARING 3-PYRIDYL GROUPS, PROCESS FOR PREPARING THE SAME AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2009-08-19 | — | — | EP | disclosed |